Detailed information NTG1009060

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: H0503_RS07630
• Genome accession: NZ_LR822009
• Coordinates: 1469187..1469972 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus isolate STH_CIRM_19
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1464187..1474972

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0503_RS07595 (STHERMO_1694)	gatC	1464249..1464551 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
H0503_RS07600	-	1464691..1464945 (-)	255	WP_024010053.1	glycosyl transferase	-
H0503_RS07605 (STHERMO_1696)	-	1464958..1465167 (-)	210	WP_080998437.1	glycosyltransferase	-
H0503_RS07610	-	1465483..1466927 (-)	1445	Protein_1466	6-phospho-beta-glucosidase	-
H0503_RS07615 (STHERMO_1699)	msrA	1467080..1467589 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H0503_RS07620 (STHERMO_1700)	-	1467601..1468449 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
H0503_RS07625 (STHERMO_1701)	-	1468573..1469124 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
H0503_RS07630 (STHERMO_1702)	codY	1469187..1469972 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
H0503_RS07635 (STHERMO_1703)	-	1470232..1471446 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
H0503_RS07640 (STHERMO_1704)	-	1471801..1472253 (+)	453	WP_002946987.1	universal stress protein	-
H0503_RS10025	-	1472433..1473004 (+)	572	Protein_1473	IS30 family transposase	-
H0503_RS07645 (STHERMO_1707)	-	1473076..1473249 (-)	174	WP_011681546.1	hypothetical protein	-
H0503_RS07650 (STHERMO_1708)	-	1473310..1473684 (-)	375	WP_011681547.1	membrane protein	-
H0503_RS07655 (STHERMO_1710)	pflA	1473896..1474696 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=1009060 H0503_RS07630 WP_002951720.1 1469187..1469972(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_19]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=1009060 H0503_RS07630 WP_002951720.1 1469187..1469972(-) (codY) [Streptococcus thermophilus isolate STH_CIRM_19]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502