I. Information of IME
ICEberg ID162_IME
Name IMESp2907  This IME is derived from experimental literature
OrganismStreptococcus pyogenes iB21
Size (bp)12.6 kb
GC content [Genome] (%)
Insertion siteInternal site of orf8 from ICESp2905 and orf10 from ICESp1108
Functionerm(TR) (macrolide, lincosamide, streptogramin)
Species that IME can be transferred toStreptococcus pyogenes; Streptococcus agalactiae
Nucleotide SequenceFR691055 (complete IME sequence in this contig)
Putative oriT region -
Putative relaxase coordinates: 12685..14325;   Family:  MOBQ

II. IME interaction with ICE/CIME/Plasmids

The Interaction Network among ICE/IME/CIME/plasmid

Detailed Informatioin of the Interaction Network
# IME  Inter_Ele [Type] Methods Donors Recipients Exper_Ref 
1IMESp2907 ICESp2905 [ICE] insolicoin cis - - -
2IMESp2907 ICESagTR7 [ICE] experimentalin cis Streptococcus agalactiae SagTR7 Streptococcus agalactiae 1357RF 26679245

experimental This is an interactioin derived from experimental literature
insolico This is a putative interactioin

The graph information of IMESp2907 components from FR691055
Complete gene list of IMESp2907 from FR691055
#GeneCoordinates [+/-], size (bp) Product *Reannotation 
1-1838..2122 [+], 285hypothetical protein
2-2137..2988 [+], 852Replication initiator protein A
3-2985..3836 [+], 852DNA replication protein
4-3833..4318 [+], 486hypothetical protein
5-4315..6099 [+], 1785TraG/TraD/VirD4 family bacterial conjugation protein
6-6153..6266 [+], 114hypothetical protein
7-6266..6577 [+], 312hypothetical protein
8-6581..6739 [+], 159hypothetical protein
9-6857..7075 [+], 219Transcriptional regulator
10-7079..7456 [+], 378hypothetical protein
11-7866..8303 [+], 438MarR bacterial repressor protein
12-8293..9600 [+], 1308MATE domain protein
13-9700..9813 [+], 114hypothetical protein
14erm(TR)10305..11036 [+], 732erythromycin resistance methylaseAR 
15-11253..11777 [+], 525Spectinomycin phosphotransferase
16-11823..11963 [+], 141hypothetical protein
17-12021..12335 [+], 315hypothetical protein
18-12685..14325 [+], 1641MobA/MobL family proteinRelaxase 
19-14398..14571 [+], 174hypothetical protein
20-14755..15282 [+], 528hypothetical protein
21-15485..16516 [+], 1032Nuclease of restriction endonuclease
22-16582..17310 [+], 729hypothetical protein
23-17465..17689 [+], 225hypothetical protein
24-17693..19339 [+], 1647TndX-like transposase subfamilyIntegrase 
25-19446..20309 [+], 864hypothetical protein
26-20327..20590 [+], 264hypothetical protein
27-20594..20983 [+], 390hypothetical protein
28-20895..23324 [+], 2430Type IV secretory pathway VirB4 component
flank Flanking regions
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer
virulence  Gene may be involved in adaptative function

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
(1) Guedon G; Libante V; Coluzzi C; Payot S; Leblond-Bourget N (2017). The Obscure World of Integrative and Mobilizable Elements, Highly Widespread Elements that Pirate Bacterial Conjugative Systems. Genes (Basel). 8(11). [PudMed:29165361]
(2) Morici E; Simoni S; Brenciani A; Giovanetti E; Varaldo PE; Mingoia M (2017). A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. 72(1):64-67. [PudMed:27621174] experimental
(3) Mingoia M; Morici E; Marini E; Brenciani A; Giovanetti E; Varaldo PE (2016). Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907. J Antimicrob Chemother. 71(3):593-600. [PudMed:26679245] experimental
(4) Bellanger X; Payot S; Leblond-Bourget N; Guedon G (2014). Conjugative and mobilizable genomic islands in bacteria: evolution and diversity. FEMS Microbiol Rev. 38(4):720-60. [PudMed:24372381]
(5) Giovanetti E; Brenciani A; Tiberi E; Bacciaglia A; Varaldo PE (2012). ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. Antimicrob Agents Chemother. 56(1):591-4. [PudMed:21986826] experimental
(6) Brenciani A; Tiberi E; Bacciaglia A; Petrelli D; Varaldo PE; Giovanetti E (2011). Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes. Antimicrob Agents Chemother. 55(5):2106-12. [PudMed:21343455] experimental
experimental experimental literature