 ICEberg ID | 793 |
Name  | ICESagTR7  |
| ICEO ID | ICEO_0000731 |
| Organism | Streptococcus agalactiae SagTR7 |
| Size (bp) | ~129 kb |
| GC content [Genome] (%) | - |
| Insertion site | rplL |
| Function | A composite ICE containing IMESp2907 and ICESag37741(also a comosite ICE consist of ICESde37741 and a 52 kb component), the first ICESa2603 family element carrying and capable of transferring resistance determinants for both antibiotics (erythromycin) and heavy metals (cadmium and arsenic) |
| Species that ICE can be transferred to | Streptococcus agalactiae 1357RF |
| Nucleotide Sequence | KP898896 (partial ICE sequence) |
| Putative oriT region | - |
| Putative relaxase | coordinates: 6211..7851; Locus tag: -; Family: MOBQ |
The Interaction Network among ICE/IME/CIME | ||||||
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| Detailed Informatioin of the Interaction Network | ||||||
| # | ICE | Inter_Ele [Type] | Methods | Donors | Recipients | Exper_Ref |
| 1 | ICESagTR7 | IMESp2907 [IME] | in cis | Streptococcus agalactiae SagTR7 | Streptococcus agalactiae 1357RF | 26679245 |
| This is an interactioin derived from experimental literature |
The graph information of ICESagTR7 components from KP898896 | |||||
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| Incomplete gene list of ICESagTR7 from KP898896 | |||||
| # | Gene | Coordinates [+/-], size (bp) | Product (GenBank annotation) | *Reannotation | |
| 1 | - | 1..103 [+], 103 | single-stranded DNA-binding protein | ||
| 2 | - | 107..265 [+], 159 | conjugal transfer protein | ||
| 3 | - | 383..601 [+], 219 | transcriptional regulator | ||
| 4 | - | 605..982 [+], 378 | hypothetical protein | ||
| 5 | - | 1370..1828 [+], 459 | MarR family protein | ||
| 6 | - | 1818..3149 [+], 1332 | MATE-like superfamily protein | ||
| 7 | - | 3226..3339 [+], 114 | hypothetical protein | ||
| 8 | erm(TR) | 3831..4562 [+], 732 | erythromycin resistance methylase | AR | |
| 9 | - | 4863..5303 [+], 441 | Spectinomycin phosphotransferase | ||
| 10 | - | 5349..5489 [+], 141 | hypothetical protein | ||
| 11 | - | 5547..5861 [+], 315 | hypothetical protein | ||
| 12 | - | 6211..7851 [+], 1641 | MobA/MobL family protein | Relaxase, MOBQ Family | |
| 13 | - | 7925..8098 [+], 174 | hypothetical protein | ||
| 14 | - | 8282..8809 [+], 528 | PF12687 domain protein | ||
| 15 | - | 9012..10043 [+], 1032 | DUF1016 superfamily protein | ||
| 16 | - | 10109..10837 [+], 729 | phage replisome organizer N-terminal domain protein | ||
| 17 | - | 10992..11216 [+], 225 | hypothetical protein | ||
| 18 | tndX | 11220..12866 [+], 1647 | Ser_recombinase superfamily protein | Integrase | |
| 19 | - | 13056..13213 [+], 158 | membrane protein | ||
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(1) Morici E; Simoni S; Brenciani A; Giovanetti E; Varaldo PE; Mingoia M (2017). A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. 72(1):64-67. [PubMed:27621174]
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(2) Mingoia M; Morici E; Marini E; Brenciani A; Giovanetti E; Varaldo PE (2016). Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907. J Antimicrob Chemother. 71(3):593-600. [PubMed:26679245]
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| experimental literature |