ICEberg
I. Information of ICE
ICEberg ID439
Name ICESp2905 This ICE is derived from experimental literature
ICEO ID ICEO_0000180
OrganismStreptococcus pyogenes iB21
Size (bp)65575
GC content [Genome] (%)36.4
Insertion siterum (23S rRNA m(5)U 1939 methyltransferase)
FunctionAntibiotic resistance conferred by erm(TR) and tet(O) gene
Species that ICE can be transferred toStreptococcus pyogenes 24RF
Nucleotide SequenceFR691055 (complete ICE sequence in this GenBank file)
Replicon-
Coordinates1659..67233 
Putative oriT region -
Putative relaxase -


II. ICE interaction with IME/CIME/

The Interaction Network among ICE/IME/CIME


Detailed Informatioin of the Interaction Network
# ICE  Inter_Ele [Type] Methods Donors Recipients Exper_Ref 
1ICESp2905 IMESp2907  [IME] insolicoin cis - - -
2ICESp2905 Tet(O) element  [IME] insolicoin trans - - -

insolico This is a putative interactioin



The graph information of ICESp2905 components from FR691055
Complete gene list of ICESp2905 from FR691055
#Gene Coordinates [+/-], size (bp) Product 
(GenBank annotation)		 *Reannotation 
1rum285..1679 [+], 139523S rRNA m(5)U 1939 methyltransferase
2-1838..2122 [+], 285hypothetical protein
3-2137..2988 [+], 852Replication initiator protein A
4-2985..3836 [+], 852DNA replication protein
5-3833..4318 [+], 486hypothetical protein
6-4315..6099 [+], 1785TraG/TraD/VirD4 family bacterial conjugation protein
7-6153..6266 [+], 114hypothetical protein
8-6266..6577 [+], 312hypothetical protein
9-6581..6739 [+], 159hypothetical protein
10-6857..7075 [+], 219Transcriptional regulator
11-7079..7456 [+], 378hypothetical protein
12-7866..8303 [+], 438MarR bacterial repressor protein
13-8293..9600 [+], 1308MATE domain protein
14-9700..9813 [+], 114hypothetical protein
15erm(TR)10305..11036 [+], 732erythromycin resistance methylase
16-11253..11777 [+], 525Spectinomycin phosphotransferase
17-11823..11963 [+], 141hypothetical protein
18-12021..12335 [+], 315hypothetical protein
19-12685..14325 [+], 1641MobA/MobL family protein
20-14398..14571 [+], 174hypothetical protein
21-14755..15282 [+], 528hypothetical protein
22-15485..16516 [+], 1032Nuclease of restriction endonuclease
23-16582..17310 [+], 729hypothetical protein
24-17465..17689 [+], 225hypothetical protein
25-17693..19339 [+], 1647TndX-like transposase subfamily
26-19446..20309 [+], 864hypothetical protein
27-20327..20590 [+], 264hypothetical protein
28-20594..20983 [+], 390hypothetical protein
29-20895..23324 [+], 2430Type IV secretory pathway VirB4 component
30-23328..25427 [+], 2100hypothetical protein
31-25685..27217 [+], 1533hypothetical protein
32-27214..29028 [+], 1815DNA topoisomerase IA
33-29110..30654 [+], 1545Divergent AAA domain protein
34-30738..38039 [+], 7302Truncated helicase
35-38020..38394 [+], 375TnpV, transposase-like protein
36tet(O)38761..40680 [+], 1920tetracycline resistance protein
37-40732..40905 [+], 174hypothetical protein
38-41327..41911 [+], 585RNA polymerase sigma factor, sigma-70 region 4
39-42006..42437 [+], 432RNA polymerase sigma factor sigma-70 family
40-42514..42684 [+], 171hypothetical protein
41-42775..42987 [+], 213hypothetical protein
42-43142..44167 [+], 1026Replicative helicase RepA
43-44560..45657 [+], 1098Plasmid recombination protein Mob family
44-45666..46520 [+], 855ParB-like nuclease domain
45-46566..46796 [+], 231hypothetical protein
46-46796..47059 [+], 264hypothetical protein
47-47114..48970 [+], 1857TndX-like transposase subfamily
48-49649..51310 [+], 1662Reverse transcriptase with group II intron
49-51444..52793 [+], 1350hypothetical protein
50-52836..53495 [+], 660hypothetical protein
51-53564..54895 [-], 1332Relaxases/mobilisation nuclease domain protein
52-54898..55254 [-], 357hypothetical protein
53-55576..56199 [+], 624Bacterial regulatory protein TetR family
54-56293..58059 [+], 1767ABC transporter family protein
55-58053..59786 [+], 1734ABC transporter family protein
56-59867..60448 [+], 582hypothetical protein
57-60448..61182 [+], 735ABC-type cobalt transport system
58-61118..62659 [+], 1542Domain I of the ABC component of a cobalt transport family protein
59-62691..64043 [+], 1353MATE domain protein
60-64286..64774 [+], 489RNA polymerase sigma factor, sigma 70 family
61-65229..65375 [+], 147hypothetical protein
62-65434..67233 [+], 1800Putative recombinase
63pnp67533..68045 [+], 513phosphorylase
 
flank Flanking regions

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins61Fasta
(1) Giovanetti E; Brenciani A; Tiberi E; Bacciaglia A; Varaldo PE (2012). ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. Antimicrob Agents Chemother. 56(1):591-4. [PubMed:21986826] experimental
(2) Brenciani A; Tiberi E; Bacciaglia A; Petrelli D; Varaldo PE; Giovanetti E (2011). Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes. Antimicrob Agents Chemother. 55(5):2106-12. [PubMed:21343455] experimental
 
experimental experimental literature

Genomics & Bioinformatics Group in MML, SJTU