Detailed information of relaxase

Relaxase

• ID: 108
• GenBank: YP_001911166
• Name: TrwC_pIE321
• UniProt ID: A7KZU5
• Family: MOB_F
• PDB ID: _
• Length: 966 a.a.
• Note: conjugative relaxase

Protein sequence

• Length: 966 a.a.
• Molecular weight: 107579.95 Da
• Isoelectric Point: 9.8802

>YP_001911166.1 TrwC (plasmid) [Salmonella enterica subsp. enterica serovar Dublin]
MLSHMVLTRQDIGRAASYYEDGADDYYAKDGDASEWQGKGAEELGLSGEVDSKRFRELLAGNIGEGHRIM
RSATRQDSKERIGLDLTFSAPKSVSLQALVAGDAEIIKAHDRAVARTLEQAEARAQARQKIQGKTRIETT
GNLVIGKFRHETSRERDPQLHTHAVILNMTKRSDGQWRALKNDEIVKATRYLGAVYNAELAHELQKLGYQ
LRYGKDGNFDLAHIDRQQIEGFSKRTEQIAEWYAARGLDPNSVSLEQKQAAKVLSRAKKTSVDREALRAE
WQATAKELGIDFSRREWSGREKGGSEKQAHSFMPSDEAAKRAVRYAINHLTERQSVMDERELVDTAMKHA
VRAARLEDIQKELLRQTETGYLIREAPRYRPGGQTGPTDEPGKTRAEWVAELAAKGMKQGAARERVDNAI
KTGGLVPIEPRYTTQTALEREKRILQIERDGRGAVAPVIAAEVARERLASTNLNQGQREAAELIVSAANR
VVGVQGFAGTGKSHMLDTAKQMIEGEGYHVRALAPYGSQVKALRELNVEANTLASFLRAKDKNIDSRTVL
VIDEAGVVPTRLMEQTLKLAEKAGARVVLMGDTAQTKAIEAGRPFDQLQAAGMQTAHMREIQRQKNPELK
VAVELAASGKASSSLERIKDVTEIKDHHERRAAVAEAYIALKPDERDRTLIVSGTNEARREINQMVREGL
GTAGKGIEFDTLVRVDTTQAERRHSKNYQVGHVIQPERDYAKTGLQRGELYRVVDTGPGNRLTVVGERDG
QRIQFSPMTHTKISVYQPERAELAVGDMVRITRNDKDLDLANGDRMKVVAVEDRKVTVTDGKRNVELPTD
KPLHVDHAYATTVHSSQGLTSDRVLIDAHAESRTTAKDVYYVAISRARFEARVFTNDRGKLPAAIARENI
KSAAHDLARDRGGRSAAAERQREQQREAERNRQTQQPAHDRQKAAREAERGMEAGR

Protein domains

Predicted by InterproScan

• AAA domain (AAA_30) (473-657)

• TrwC relaxase (TrwC) (13-287)

Protein structure

• AlphaFold DB: A7KZU5

Reference

[1] Revilla C et al. (2008) Different pathways to acquiring resistance genes illustrated by the recent evolution of IncW plasmids. Antimicrob Agents Chemother. 52(4):1472-80. [PMID:18268088]