oriTDB: a web-based resource for the origin sites of DNA transfer (oriT)
in bacterial mobile genetic elements |
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Bacterial mobile genetic elements (MGEs), such as integrative and conjugative elements (ICEs) and plasmids, have been highlighted as important vehicles for dissemination of pathogenesis and antimicrobial-resistance determinants.
The mechanism of DNA processing and replication include an origin region of transfer (oriT), a relaxase, other conjugation transfer proteins and the ability to undergo rolling-circle, extrachromosomal replication.
oriTfinder is a web server that facilitates rapid identification of the origin site of DNA transfer (oriT) of a conjugative plasmid or a chromosome-borne integrative and conjugative element. The database oriTDB currently contains details of transfer origin regions (oriT), nicking sites (nic), relaxases and auxiliary DNA-binding proteins, type IV coupling proteins (T4CP), as well as a collection of directly related references. Citation: X. Li, Y. Xie, M. Liu, C. Tai, J. Sun, Z. Deng, H.Y. Ou (2018) oriTfinder: a web-based tool for the identification of origin of transfers in DNA sequences of bacterial mobile genetic elements. Nucleic Acids Research, 46(W1):W229–W234. DOI: 10.1093/nar/gky352. [Abstract] |
Current version: 1.0 | Since: May 2017 |
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