Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 532947..533641 Replicon chromosome
Accession NZ_CP027714
Organism Pseudomonas chlororaphis strain ATCC 17415

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4K25_RS02395 Protein ID WP_097134270.1
Coordinates 532947..533243 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4K25_RS02400 Protein ID WP_009041852.1
Coordinates 533240..533641 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K25_RS02360 528568..529113 - 546 WP_007926837.1 hypothetical protein -
C4K25_RS02365 529110..529364 - 255 WP_007926835.1 acyl carrier protein -
C4K25_RS02370 529374..529634 - 261 WP_007926834.1 acyl carrier protein -
C4K25_RS02375 529609..530424 - 816 WP_114760259.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
C4K25_RS02380 530400..531131 - 732 WP_037004440.1 beta-ketoacyl synthase chain length factor -
C4K25_RS02385 531466..532236 + 771 WP_009041850.1 ParA family protein -
C4K25_RS02390 532275..532709 - 435 WP_062823885.1 thioredoxin TrxC -
C4K25_RS02395 532947..533243 + 297 WP_097134270.1 type II toxin-antitoxin system HigB family toxin Toxin
C4K25_RS02400 533240..533641 + 402 WP_009041852.1 transcriptional regulator Antitoxin
C4K25_RS02405 533645..535108 - 1464 WP_097134272.1 YdiU family protein -
C4K25_RS02410 535157..538507 - 3351 WP_114760260.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11560.36 Da        Isoelectric Point: 10.6515

>T99938 WP_097134270.1 NZ_CP027714:532947-533243 [Pseudomonas chlororaphis]
MHIITAKRIWEAKSRWPQSANALETWYRKAKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

>T99938 NZ_CP027714:532947-533243 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAGCCGCTGGCCACAATCGGCCAATGCGCTGGAAACCTGGTA
CAGAAAAGCCAAAAGCCTCAATCCGGCCGATTTTGCAGCCATCAAGGCGGTATTTCCGGCCACCGACAAAGTAGGGGCGT
TTCACGTCTTCGATATTGGTGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAAGTACGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAAGGCAGGTGGAAGGAGGAAACCAGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14854.92 Da        Isoelectric Point: 4.5430

>AT99938 WP_009041852.1 NZ_CP027714:533240-533641 [Pseudomonas chlororaphis]
MNVLVKQAADHWHFVAPVLRKPKTEADYDALVAALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp

>AT99938 NZ_CP027714:533240-533641 [Pseudomonas chlororaphis]
ATGAACGTTCTGGTGAAGCAGGCGGCGGATCATTGGCATTTCGTGGCGCCTGTGTTGCGTAAACCCAAGACCGAAGCCGA
TTACGATGCATTGGTCGCGGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGACTGGATCGAAGCCTACGACGAAGAGCATCGACCGATGCCGATAGCCAGTGGTGTTGACGTCTTG
CGCTCCCTGATGCGCGAACACGGCCTGACCCAGAGCGATCTGCCAGGCGTGGGTGCACAGTCGGTGGTTTCCGAAGTGCT
GAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTCTTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References