Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 537533..538227 Replicon chromosome
Accession NZ_CP027708
Organism Pseudomonas chlororaphis subsp. piscium strain ATCC 17411

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4K37_RS02430 Protein ID WP_053268076.1
Coordinates 537533..537829 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4K37_RS02435 Protein ID WP_124323351.1
Coordinates 537826..538227 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K37_RS02395 533070..533615 - 546 WP_025808153.1 membrane protein -
C4K37_RS02400 533612..533866 - 255 WP_007926835.1 acyl carrier protein -
C4K37_RS02405 533876..534136 - 261 WP_025808152.1 acyl carrier protein -
C4K37_RS02410 534111..534926 - 816 WP_124323349.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
C4K37_RS02415 534902..535633 - 732 WP_036998144.1 beta-ketoacyl synthase chain length factor -
C4K37_RS02420 535965..536735 + 771 WP_097305890.1 ParA family protein -
C4K37_RS02425 536861..537295 - 435 WP_124323350.1 thioredoxin TrxC -
C4K37_RS02430 537533..537829 + 297 WP_053268076.1 type II toxin-antitoxin system HigB family toxin Toxin
C4K37_RS02435 537826..538227 + 402 WP_124323351.1 transcriptional regulator Antitoxin
C4K37_RS02440 538232..539695 - 1464 WP_124323352.1 YdiU family protein -
C4K37_RS02445 539744..543091 - 3348 WP_124323353.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11588.41 Da        Isoelectric Point: 10.6515

>T99902 WP_053268076.1 NZ_CP027708:537533-537829 [Pseudomonas chlororaphis subsp. piscium]
MHIITAKRIWEAKSRWPQSANALETWYRKVKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

>T99902 NZ_CP027708:537533-537829 [Pseudomonas chlororaphis subsp. piscium]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAGTCGCTGGCCGCAATCGGCCAATGCGCTGGAGACCTGGTA
CAGAAAAGTCAAAAGCCTCAATCCGGCTGATTTTGCAGCTATCAAGGCGGTGTTTCCGGCCACCGACAAAGTGGGGGCGT
TTCACGTCTTCGATATTGGCGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAAGTGCGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAGGGCAGGTGGAAGGAGGAAACCAGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14925.01 Da        Isoelectric Point: 4.5517

>AT99902 WP_124323351.1 NZ_CP027708:537826-538227 [Pseudomonas chlororaphis subsp. piscium]
MNVLVRQAAEHWHFVAPVLRKPKTEADYDALVVALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp

>AT99902 NZ_CP027708:537826-538227 [Pseudomonas chlororaphis subsp. piscium]
ATGAATGTTCTGGTGAGGCAGGCGGCGGAGCATTGGCATTTCGTCGCCCCTGTGTTGCGTAAACCCAAGACCGAAGCCGA
TTACGATGCATTGGTCGTGGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGATTGGATCGAAGCCTACGACGAAGAGCATCGACCGATGCCGATAGCCAGTGGCGTTGATGTCTTG
CGCTCCCTGATGCGCGAACATGGCCTGACCCAGAGCGATCTGCCAGGCGTGGGTGCGCAGTCGGTGGTTTCGGAAGTGCT
GAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTATTTATCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References