Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 535505..536199 Replicon chromosome
Accession NZ_CP027706
Organism Pseudomonas sp. CMR12a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4K39_RS02430 Protein ID WP_124345580.1
Coordinates 535505..535801 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4K39_RS02435 Protein ID WP_022640300.1
Coordinates 535798..536199 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K39_RS02395 531136..531681 - 546 WP_124345577.1 hypothetical protein -
C4K39_RS02400 531678..531932 - 255 WP_068578636.1 acyl carrier protein -
C4K39_RS02405 531942..532214 - 273 WP_068578634.1 acyl carrier protein -
C4K39_RS02410 532183..533004 - 822 WP_124345578.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
C4K39_RS02415 532980..533708 - 729 WP_124345579.1 beta-ketoacyl synthase chain length factor -
C4K39_RS02420 534020..534790 + 771 WP_068578628.1 ParA family protein -
C4K39_RS02425 534842..535276 - 435 WP_068578626.1 thioredoxin TrxC -
C4K39_RS02430 535505..535801 + 297 WP_124345580.1 type II toxin-antitoxin system HigB family toxin Toxin
C4K39_RS02435 535798..536199 + 402 WP_022640300.1 transcriptional regulator Antitoxin
C4K39_RS02440 536201..537664 - 1464 WP_124345581.1 YdiU family protein -
C4K39_RS02445 537734..541060 - 3327 WP_124345582.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11552.39 Da        Isoelectric Point: 10.3534

>T99888 WP_124345580.1 NZ_CP027706:535505-535801 [Pseudomonas sp. CMR12a]
MHIITAKRIWQAKEQWPQSARALDTWYRKAKGARPEDFSDMKALFPAVDKVGRFHVFDIGGNKLRLIALVRYGVQRLYIR
HVLDHASYDKGLWKEEIE

Download         Length: 297 bp

>T99888 NZ_CP027706:535505-535801 [Pseudomonas sp. CMR12a]
ATGCATATCATCACCGCAAAACGTATCTGGCAGGCCAAGGAGCAGTGGCCGCAGAGCGCACGAGCGCTGGATACCTGGTA
TCGCAAGGCCAAGGGCGCCAGGCCAGAGGACTTTTCCGATATGAAGGCGTTGTTTCCGGCGGTCGATAAGGTCGGGCGCT
TCCATGTCTTCGACATCGGCGGCAACAAACTGCGGTTGATCGCACTGGTGCGCTATGGAGTCCAGCGGCTCTACATCAGG
CATGTACTGGACCACGCCAGCTACGACAAGGGGCTGTGGAAGGAGGAAATAGAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14866.97 Da        Isoelectric Point: 4.4569

>AT99888 WP_022640300.1 NZ_CP027706:535798-536199 [Pseudomonas sp. CMR12a]
MSILVSQAAEHWQFVAPLLRKPRTEADYDALALALDELLDIMGEDEAHPLASLVDIIGDWIEAYDEEHRPIPPVSGVEVL
RSLMHEHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQVRWLSERFKVAMEVFA

Download         Length: 402 bp

>AT99888 NZ_CP027706:535798-536199 [Pseudomonas sp. CMR12a]
ATGAGCATACTGGTCAGCCAGGCGGCGGAGCACTGGCAATTCGTCGCGCCGCTGCTGCGCAAGCCCAGGACCGAGGCCGA
TTACGATGCTCTGGCCCTGGCCCTGGATGAATTGCTGGACATCATGGGCGAGGATGAGGCTCATCCGCTGGCCTCACTGG
TGGACATCATCGGTGATTGGATCGAGGCCTATGACGAAGAGCATCGGCCGATACCTCCCGTCAGTGGCGTGGAGGTCTTG
CGCTCGTTGATGCACGAGCACGGCCTGACCCAGAGCGACCTGCCCGGGGTCGGGGCGCAATCGGTGGTTTCCGAAGTGCT
GAGTGGCAAGCGCCAGCTCAACCTGCGGCAGGTGCGCTGGCTGTCCGAGCGCTTCAAGGTGGCAATGGAAGTGTTCGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References