Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 7140..7712 Replicon plasmid unnamed1
Accession NZ_CP027670
Organism Simplicispira suum strain SC1-8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C6571_RS18185 Protein ID WP_106448343.1
Coordinates 7140..7418 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C6571_RS18190 Protein ID WP_106448344.1
Coordinates 7428..7712 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6571_RS18145 2210..2392 + 183 WP_013516270.1 hypothetical protein -
C6571_RS18150 2609..2923 + 315 WP_013516271.1 hypothetical protein -
C6571_RS18155 2933..3253 + 321 WP_013516272.1 hypothetical protein -
C6571_RS18160 3332..3793 + 462 WP_013516273.1 hypothetical protein -
C6571_RS18165 4042..4425 + 384 WP_013516274.1 hypothetical protein -
C6571_RS18170 4422..4670 + 249 WP_013516275.1 hypothetical protein -
C6571_RS19610 4743..4955 + 213 WP_146139379.1 hypothetical protein -
C6571_RS18175 5145..6242 + 1098 WP_106448341.1 hypothetical protein -
C6571_RS18180 6415..7095 + 681 WP_106448342.1 site-specific integrase -
C6571_RS18185 7140..7418 + 279 WP_106448343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6571_RS18190 7428..7712 + 285 WP_106448344.1 HigA family addiction module antidote protein Antitoxin
C6571_RS18195 7712..7939 + 228 WP_106448345.1 hypothetical protein -
C6571_RS18200 7992..8198 + 207 WP_106448346.1 hypothetical protein -
C6571_RS18205 8442..8663 + 222 WP_106448347.1 hypothetical protein -
C6571_RS18210 8682..8948 + 267 WP_106448348.1 hypothetical protein -
C6571_RS18215 8961..9296 + 336 WP_170094851.1 hypothetical protein -
C6571_RS19615 9310..9630 + 321 WP_146139380.1 hypothetical protein -
C6571_RS19780 9854..10018 + 165 WP_170094853.1 hypothetical protein -
C6571_RS18220 10031..10630 + 600 WP_106448349.1 hypothetical protein -
C6571_RS18225 10642..10824 + 183 WP_106448350.1 hypothetical protein -
C6571_RS19620 10839..11114 + 276 WP_146139381.1 hypothetical protein -
C6571_RS18230 11568..12176 + 609 WP_106448351.1 phospholipase D family protein -
C6571_RS18235 12229..12594 + 366 WP_013516303.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid cmlA1 / aadA2 / sul1 - 1..140077 140077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10290.83 Da        Isoelectric Point: 10.2252

>T99844 WP_106448343.1 NZ_CP027670:7140-7418 [Simplicispira suum]
MIKSFRHKGLQRYFETGSKAGIQAAHAPRLRLQLAALNQATKPEDMSAPAWALHPLKGGLKGHWAVTVNGNWRMVFTFDG
TDAVLVDYLDYH

Download         Length: 279 bp

>T99844 NZ_CP027670:7140-7418 [Simplicispira suum]
ATGATCAAGAGCTTCAGGCACAAAGGGCTGCAGCGGTATTTTGAGACAGGGAGCAAGGCGGGCATTCAAGCTGCACACGC
CCCTCGGCTGCGTTTGCAACTGGCGGCCCTCAACCAGGCAACCAAGCCCGAAGACATGTCGGCTCCTGCTTGGGCGCTTC
ACCCATTGAAAGGTGGCCTAAAAGGGCATTGGGCCGTCACCGTGAATGGCAACTGGCGCATGGTTTTCACCTTCGACGGA
ACCGACGCTGTATTGGTGGACTACCTGGACTACCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10387.97 Da        Isoelectric Point: 10.0915

>AT99844 WP_106448344.1 NZ_CP027670:7428-7712 [Simplicispira suum]
MTKMHNPPHPGEVLREYLGEVTVTDAAQQLGVNRVTLTRIVSGHSGISPDMAFRLASAFGTSPELWAGMQMQYDLYQASK
AKRPRIHRITVVPA

Download         Length: 285 bp

>AT99844 NZ_CP027670:7428-7712 [Simplicispira suum]
ATGACCAAGATGCACAACCCTCCGCACCCCGGCGAAGTCCTGCGCGAATACCTTGGAGAGGTGACCGTAACGGACGCGGC
CCAGCAGCTCGGCGTGAACCGCGTCACGCTGACACGCATCGTCTCGGGGCATTCGGGAATTTCCCCTGACATGGCTTTTC
GCCTGGCAAGCGCGTTTGGAACGAGTCCTGAACTCTGGGCAGGCATGCAGATGCAGTACGACCTGTACCAGGCCAGCAAG
GCGAAGCGTCCGCGCATTCATCGCATCACTGTGGTTCCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References