Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3285393..3285964 Replicon chromosome
Accession NZ_CP027667
Organism Melaminivora sp. SC2-9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C6568_RS15390 Protein ID WP_106684921.1
Coordinates 3285686..3285964 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag C6568_RS15385 Protein ID WP_106684920.1
Coordinates 3285393..3285686 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6568_RS15360 3281515..3282600 - 1086 WP_106684915.1 cell envelope integrity protein TolA -
C6568_RS15365 3282635..3283060 - 426 WP_106684916.1 ExbD/TolR family protein -
C6568_RS15370 3283062..3283775 - 714 WP_106684917.1 protein TolQ -
C6568_RS15375 3283772..3284191 - 420 WP_106684918.1 tol-pal system-associated acyl-CoA thioesterase -
C6568_RS15380 3284198..3285382 - 1185 WP_106684919.1 pyridoxal phosphate-dependent aminotransferase -
C6568_RS15385 3285393..3285686 - 294 WP_106684920.1 HigA family addiction module antidote protein Antitoxin
C6568_RS15390 3285686..3285964 - 279 WP_106684921.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6568_RS15395 3285989..3286546 - 558 WP_106684922.1 transcription antitermination factor NusB -
C6568_RS15400 3286543..3287031 - 489 WP_106684923.1 6,7-dimethyl-8-ribityllumazine synthase -
C6568_RS15405 3287074..3288195 - 1122 WP_106684924.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
C6568_RS15410 3288338..3288631 - 294 WP_106684925.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
C6568_RS15415 3289021..3289938 + 918 WP_106684926.1 aminotransferase class IV -
C6568_RS15420 3290025..3290948 + 924 WP_106684927.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10555.97 Da        Isoelectric Point: 9.6576

>T99833 WP_106684921.1 NZ_CP027667:c3285964-3285686 [Melaminivora sp. SC2-9]
VIKSFRHKGLRRLFESGNASGVQAAHVRRLRMQLAALDTAQVLGDMDLPGFRLHPLKGEHQGRWSITVNGNWRMTFEFEG
GNAYILDYEDYH

Download         Length: 279 bp

>T99833 NZ_CP027667:c3285964-3285686 [Melaminivora sp. SC2-9]
GTGATCAAGTCGTTTCGTCACAAAGGTCTGCGCCGGCTGTTTGAGTCGGGAAACGCGTCTGGCGTGCAAGCCGCCCACGT
GCGGCGGCTCCGCATGCAGCTGGCGGCTTTGGATACGGCCCAGGTTCTCGGCGATATGGACCTCCCGGGCTTTCGGCTGC
ATCCGCTCAAGGGCGAACACCAGGGCCGCTGGTCCATCACCGTGAACGGCAACTGGCGCATGACGTTCGAATTTGAAGGC
GGCAATGCCTATATCCTGGACTACGAGGACTACCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10669.30 Da        Isoelectric Point: 7.4036

>AT99833 WP_106684920.1 NZ_CP027667:c3285686-3285393 [Melaminivora sp. SC2-9]
MAMHNPPHPGEFISDVYLEPHGISGRELADKLDVAASTLSRILKGSSRVTPEMALRLSKALGRTPESWLAMQDAHDLWQA
RQSVDLARVGKLQLAII

Download         Length: 294 bp

>AT99833 NZ_CP027667:c3285686-3285393 [Melaminivora sp. SC2-9]
ATGGCCATGCATAACCCACCCCATCCTGGCGAGTTCATCTCGGACGTCTATCTCGAGCCGCACGGCATCAGCGGGCGTGA
GCTGGCGGACAAGCTCGACGTGGCGGCATCCACCCTGAGCCGTATCCTCAAGGGCAGCAGCCGGGTCACGCCCGAGATGG
CGCTGCGCCTGTCCAAGGCGCTGGGCCGCACGCCCGAGAGCTGGCTGGCCATGCAGGACGCGCACGACCTGTGGCAGGCA
CGCCAGAGCGTCGACCTGGCGCGCGTGGGCAAGCTGCAGCTGGCCATCATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References