Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2601443..2602092 Replicon chromosome
Accession NZ_CP027667
Organism Melaminivora sp. SC2-9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C6568_RS12175 Protein ID WP_106684347.1
Coordinates 2601443..2601781 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C6568_RS12180 Protein ID WP_106684348.1
Coordinates 2601778..2602092 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6568_RS12145 2596643..2597968 + 1326 Protein_2378 AAA family ATPase -
C6568_RS12150 2598025..2598827 + 803 WP_106682576.1 IS5 family transposase -
C6568_RS12160 2599215..2599682 - 468 WP_158702882.1 hypothetical protein -
C6568_RS12165 2599685..2600749 - 1065 WP_106685495.1 hypothetical protein -
C6568_RS12170 2600906..2601199 + 294 WP_106684346.1 helix-turn-helix transcriptional regulator -
C6568_RS12175 2601443..2601781 + 339 WP_106684347.1 toxin Toxin
C6568_RS12180 2601778..2602092 + 315 WP_106684348.1 transcriptional regulator Antitoxin
C6568_RS12185 2602092..2602967 + 876 WP_106684349.1 EamA family transporter RarD -
C6568_RS12190 2603047..2603580 - 534 WP_106685496.1 DedA family protein -
C6568_RS12195 2603702..2604529 + 828 WP_106684350.1 M15 family metallopeptidase -
C6568_RS12200 2604580..2605452 + 873 WP_106684351.1 cytochrome c -
C6568_RS12205 2605595..2606641 + 1047 WP_106684352.1 tRNA dihydrouridine synthase DusB -
C6568_RS12210 2606638..2606931 + 294 WP_106684353.1 Fis family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2598486..2598827 341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(45-101)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12721.60 Da        Isoelectric Point: 10.1671

>T99832 WP_106684347.1 NZ_CP027667:2601443-2601781 [Melaminivora sp. SC2-9]
MKAVFVELPAFSRHRARYLDDEGLRSLQEAMMRDPQAGDVIEGAGGLRKLRHGDPRRGKGKRGGLRVIYYWWDGGAQFWL
FTLFDKDEAADLSADERLALKGMLKAALEARR

Download         Length: 339 bp

>T99832 NZ_CP027667:2601443-2601781 [Melaminivora sp. SC2-9]
ATGAAAGCCGTCTTCGTCGAGTTGCCGGCCTTCTCGCGCCACCGCGCCCGCTATCTGGACGACGAAGGCTTGCGTAGCCT
GCAGGAGGCCATGATGCGCGATCCCCAGGCGGGCGACGTGATCGAGGGCGCGGGCGGCCTGCGCAAATTGCGCCATGGCG
ATCCACGCCGGGGCAAGGGCAAGCGCGGCGGCTTGCGGGTGATCTATTACTGGTGGGATGGCGGGGCGCAGTTCTGGCTG
TTCACCCTGTTCGACAAGGATGAAGCGGCCGACCTGAGCGCGGATGAAAGGTTGGCCTTGAAGGGCATGTTGAAGGCAGC
GTTGGAGGCAAGGCGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11803.52 Da        Isoelectric Point: 10.0685

>AT99832 WP_106684348.1 NZ_CP027667:2601778-2602092 [Melaminivora sp. SC2-9]
MSGRNLFAEISEGFEALEDARAGKRTLRTHEVELKPAPDITAGELLALRERLHLSRPVFARYLRTNPRTLENWEQGRARP
NAQAALLIRLVEKFPDTVERLAAV

Download         Length: 315 bp

>AT99832 NZ_CP027667:2601778-2602092 [Melaminivora sp. SC2-9]
ATGAGCGGGCGGAATTTGTTTGCCGAGATTTCCGAGGGCTTCGAGGCCCTGGAAGATGCGCGCGCCGGCAAGCGCACGTT
GCGCACGCACGAGGTGGAGCTCAAGCCTGCCCCGGACATCACGGCCGGTGAGCTGCTGGCTCTGCGCGAGCGGCTGCACC
TGTCACGCCCGGTCTTCGCCCGCTACCTGCGCACCAATCCGCGCACGCTGGAAAACTGGGAGCAGGGCCGAGCCAGACCC
AACGCCCAGGCGGCGCTGCTGATCCGCCTGGTCGAGAAATTCCCCGATACGGTGGAGAGGCTGGCAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References