Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1831506..1832106 Replicon chromosome
Accession NZ_CP027667
Organism Melaminivora sp. SC2-9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C6568_RS08740 Protein ID WP_106683775.1
Coordinates 1831506..1831784 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C6568_RS08745 Protein ID WP_106683776.1
Coordinates 1831801..1832106 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6568_RS08715 1826543..1827199 - 657 WP_106683770.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
C6568_RS08720 1827196..1829163 - 1968 WP_106683771.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
C6568_RS08725 1829318..1829902 + 585 WP_106683772.1 NAD(P)H-dependent oxidoreductase -
C6568_RS08730 1829969..1830232 + 264 WP_158702861.1 YkgJ family cysteine cluster protein -
C6568_RS08735 1830367..1831299 - 933 WP_106683774.1 GIY-YIG nuclease family protein -
C6568_RS08740 1831506..1831784 + 279 WP_106683775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6568_RS08745 1831801..1832106 + 306 WP_106683776.1 HigA family addiction module antidote protein Antitoxin
C6568_RS08750 1832278..1832886 + 609 WP_106683777.1 glutathione transferase GstA -
C6568_RS08755 1833008..1834132 + 1125 WP_106683778.1 alkene reductase -
C6568_RS08760 1834220..1835869 - 1650 WP_106683779.1 MCP four helix bundle domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10459.05 Da        Isoelectric Point: 10.0049

>T99826 WP_106683775.1 NZ_CP027667:1831506-1831784 [Melaminivora sp. SC2-9]
MILDFRCADTQALFAGRRVARFANIEVVAMRKLVQLNAATSLDFLRRPPGNRLEALQGDRQGQYSIRINGQWRVCFVWAA
GAAHQVEIVDYH

Download         Length: 279 bp

>T99826 NZ_CP027667:1831506-1831784 [Melaminivora sp. SC2-9]
ATGATCCTCGACTTTCGGTGTGCCGACACGCAGGCGCTGTTTGCGGGCCGGCGTGTGGCGCGATTCGCCAACATCGAGGT
GGTGGCCATGCGCAAGCTGGTGCAATTGAACGCCGCGACCAGCCTGGACTTTCTGCGCCGCCCGCCCGGCAACCGGCTGG
AGGCGCTGCAAGGCGACCGCCAAGGCCAGTACAGCATCCGCATCAATGGCCAGTGGCGCGTGTGCTTCGTGTGGGCCGCA
GGCGCAGCGCACCAGGTCGAGATTGTGGACTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11321.94 Da        Isoelectric Point: 6.3249

>AT99826 WP_106683776.1 NZ_CP027667:1831801-1832106 [Melaminivora sp. SC2-9]
MPREIKWPHPGEILLHEWLEPLGLSQYALAKAIGVPARRINEIVKGLRGISADTALRFAAFFGTDAQSWINLQTDYDLAN
ARDAMADVLEHIVRHEPAQHA

Download         Length: 306 bp

>AT99826 NZ_CP027667:1831801-1832106 [Melaminivora sp. SC2-9]
ATGCCCCGTGAGATCAAATGGCCGCACCCCGGCGAGATCCTGTTGCACGAGTGGCTGGAACCACTGGGCCTGAGCCAGTA
CGCGCTGGCCAAGGCCATTGGCGTGCCAGCGCGCCGCATCAACGAAATCGTCAAGGGTCTGCGCGGCATCAGCGCCGATA
CGGCGTTGCGCTTCGCCGCGTTCTTTGGCACCGATGCGCAGAGCTGGATCAACCTGCAGACGGATTACGACCTGGCAAAC
GCACGCGACGCGATGGCCGACGTGCTGGAGCACATCGTGCGCCATGAGCCGGCGCAACACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References