Detailed information of TA system TA099824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1699060..1699763
• Replicon: chromosome
• Accession: NZ_CP027667
• Organism: Melaminivora sp. SC2-9

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: C6568_RS08145
• Protein ID: WP_106683668.1
• Coordinates: 1699464..1699763 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: C6568_RS08140
• Protein ID: WP_106683667.1
• Coordinates: 1699060..1699461 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6568_RS08120	1694692..1695624	-	933	WP_106683663.1	SMP-30/gluconolactonase/LRE family protein	-
C6568_RS08125	1695682..1696881	-	1200	WP_106683664.1	ammonium transporter	-
C6568_RS08130	1696928..1697266	-	339	WP_106683665.1	P-II family nitrogen regulator	-
C6568_RS08135	1697434..1698990	+	1557	WP_106683666.1	YifB family Mg chelatase-like AAA ATPase	-
C6568_RS08140	1699060..1699461	-	402	WP_106683667.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
C6568_RS08145	1699464..1699763	-	300	WP_106683668.1	type II toxin-antitoxin system MqsR family toxin	Toxin
C6568_RS08150	1699810..1701375	-	1566	WP_106683669.1	ATP-binding cassette domain-containing protein	-
C6568_RS08155	1701372..1703279	-	1908	WP_106683670.1	ABC transporter permease	-
C6568_RS08160	1703402..1704571	-	1170	WP_106685416.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-109)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 10802.54 Da
• Isoelectric Point: 6.2090

>T99824 WP_106683668.1 NZ_CP027667:c1699763-1699464 [Melaminivora sp. SC2-9]
MEKSTPHCKLELVKALVQAGQVRATASAYDGALELGVQDLAGMCAVVLALEPRDFYKSMTTHADHRIWQDVYRPAAPGGG
VYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 300 bp

>T99824 NZ_CP027667:c1699763-1699464 [Melaminivora sp. SC2-9]
ATGGAGAAAAGCACGCCGCATTGCAAGCTCGAGCTTGTCAAGGCTTTGGTTCAGGCGGGCCAGGTGCGCGCCACTGCCAG
CGCCTATGACGGTGCCCTGGAGTTGGGCGTTCAGGACTTGGCAGGCATGTGCGCGGTGGTATTGGCGCTCGAACCCCGCG
ACTTCTACAAGAGCATGACCACCCATGCCGACCATCGCATCTGGCAAGACGTCTACCGACCCGCAGCGCCAGGCGGCGGC
GTCTACCTCAAGCTCACCGTCATCGACGATGTCCTGATCGTTTCCTTCAAGGAGCTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14749.80 Da
• Isoelectric Point: 7.2413

>AT99824 WP_106683667.1 NZ_CP027667:c1699461-1699060 [Melaminivora sp. SC2-9]
MQCPVCGAAELIHDTRDLTHTYKGESTTIADVTGQWCPACAEVVLDRESGDRYAQCIAAFRRQVNAATIDPGYIAQVRQK
LSLDQRQAAELFGGGVNAFSRYETGRTRPPLALVQLLRLLDRHPHLLQEMKPA

Nucleotide

• Length: 402 bp

>AT99824 NZ_CP027667:c1699461-1699060 [Melaminivora sp. SC2-9]
ATGCAATGTCCCGTCTGCGGCGCGGCCGAATTGATCCACGACACGCGCGACCTCACCCACACCTACAAGGGCGAATCGAC
CACCATCGCCGACGTAACGGGCCAGTGGTGCCCGGCCTGCGCCGAGGTGGTGCTGGACCGCGAAAGCGGCGACCGCTATG
CCCAGTGCATCGCAGCGTTTCGCCGCCAGGTCAACGCCGCCACCATCGACCCCGGCTACATCGCTCAGGTGCGCCAGAAA
CTCTCCCTGGACCAGCGCCAGGCAGCCGAGCTGTTCGGCGGCGGGGTCAACGCTTTCTCGCGCTACGAGACTGGCAGGAC
GCGCCCGCCGCTGGCGCTGGTGCAGTTGCTCCGGCTGCTGGATCGCCACCCGCATCTGCTGCAGGAGATGAAACCGGCTT
GA