Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1376373..1377037 Replicon chromosome
Accession NZ_CP027663
Organism Acidiferrobacter sp. SPIII_3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4901_RS06905 Protein ID WP_110136695.1
Coordinates 1376373..1376717 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4901_RS06910 Protein ID WP_110136696.1
Coordinates 1376714..1377037 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4901_RS06880 1371762..1372976 - 1215 WP_205736247.1 Fic family protein -
C4901_RS17595 1373391..1373567 + 177 WP_168185603.1 hypothetical protein -
C4901_RS06885 1373677..1373970 - 294 WP_110136691.1 type II toxin-antitoxin system RelE/ParE family toxin -
C4901_RS06890 1373958..1374230 - 273 WP_110136692.1 CopG family ribbon-helix-helix protein -
C4901_RS06895 1374384..1374509 - 126 WP_110136693.1 transposase -
C4901_RS06900 1374506..1375510 - 1005 WP_168185604.1 ISL3 family transposase -
C4901_RS06905 1376373..1376717 + 345 WP_110136695.1 toxin Toxin
C4901_RS06910 1376714..1377037 + 324 WP_110136696.1 transcriptional regulator Antitoxin
C4901_RS06915 1377100..1377474 - 375 WP_145960642.1 hypothetical protein -
C4901_RS06920 1377704..1378228 - 525 WP_110136698.1 GNAT family N-acetyltransferase -
C4901_RS06925 1378236..1378511 - 276 WP_110136699.1 DUF1778 domain-containing protein -
C4901_RS06930 1378896..1380305 - 1410 WP_110136700.1 siroheme synthase CysG -
C4901_RS06935 1380354..1380794 - 441 WP_110136701.1 ParB/Srx family N-terminal domain-containing protein -
C4901_RS06940 1381432..1381938 - 507 WP_110136702.1 DNA repair protein RadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(44-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12862.83 Da        Isoelectric Point: 10.4966

>T99810 WP_110136695.1 NZ_CP027663:1376373-1376717 [Acidiferrobacter sp. SPIII_3]
MKAVFVELPVFSRLRQNYLDDEGFRALQATLMGNPMAGDVIQGSGGLRKVRHGGTRRGQGKRGGLRIIYYWYSLGAQFWL
FTVYDKNEASDLTAKERHTLKVLLDAELKARGTL

Download         Length: 345 bp

>T99810 NZ_CP027663:1376373-1376717 [Acidiferrobacter sp. SPIII_3]
ATGAAAGCGGTTTTTGTCGAACTGCCCGTGTTCTCCCGGTTACGCCAGAACTACCTTGATGACGAGGGGTTTCGAGCACT
CCAAGCCACTCTCATGGGCAATCCCATGGCGGGCGACGTCATCCAGGGGTCAGGCGGCCTGCGGAAAGTTCGGCATGGGG
GCACTCGTCGAGGTCAGGGGAAACGGGGCGGGTTACGTATCATCTATTACTGGTACTCGTTAGGCGCGCAGTTTTGGTTG
TTCACCGTCTATGACAAGAACGAAGCGAGCGACCTGACGGCCAAGGAACGTCACACTCTGAAAGTCCTGTTGGACGCTGA
ATTAAAGGCAAGGGGTACCCTGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12295.19 Da        Isoelectric Point: 10.8957

>AT99810 WP_110136696.1 NZ_CP027663:1376714-1377037 [Acidiferrobacter sp. SPIII_3]
VKKEKRDIFAEIREGFVALADERAGKITLTRHSIDVKPTPIVTAEEILALRERLNISRTVFARTLRTNVRTLENWEQGRA
RPNAQAALLIRMVENYPDTVERLARLS

Download         Length: 324 bp

>AT99810 NZ_CP027663:1376714-1377037 [Acidiferrobacter sp. SPIII_3]
GTGAAAAAAGAGAAGCGCGACATCTTTGCGGAAATCCGTGAAGGGTTTGTGGCACTAGCCGATGAACGGGCCGGGAAAAT
CACCCTCACTCGTCACTCCATAGATGTCAAACCGACGCCCATCGTCACGGCCGAGGAGATTCTGGCCCTGCGCGAGCGAC
TCAATATCTCGCGCACCGTCTTCGCGCGTACCCTGCGCACTAATGTCCGCACCCTGGAAAATTGGGAACAAGGCCGGGCA
CGGCCTAATGCCCAAGCCGCCCTCTTGATTCGCATGGTAGAGAACTACCCCGATACGGTGGAGCGGCTGGCGCGGCTTTC
GTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References