Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3826986..3827676 Replicon chromosome
Accession NZ_CP027657
Organism Pseudomonas mendocina strain NEB698

Toxin (Protein)


Gene name higB Uniprot ID A0A2N3H236
Locus tag C7A17_RS17800 Protein ID WP_061241945.1
Coordinates 3826986..3827351 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1G6W279
Locus tag C7A17_RS17805 Protein ID WP_074675645.1
Coordinates 3827344..3827676 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7A17_RS17765 3822117..3823319 - 1203 WP_158704679.1 nucleotidyltransferase family protein -
C7A17_RS17770 3823304..3825037 - 1734 WP_106743011.1 ABC transporter ATP-binding protein/permease -
C7A17_RS17775 3825064..3825540 - 477 WP_106739264.1 lasso peptide biosynthesis B2 protein -
C7A17_RS17780 3825552..3825833 - 282 WP_106739265.1 PqqD family peptide modification chaperone -
C7A17_RS17790 3826372..3826572 + 201 WP_158704680.1 hypothetical protein -
C7A17_RS17795 3826671..3826937 + 267 WP_106743016.1 tyrosine-type recombinase/integrase -
C7A17_RS17800 3826986..3827351 + 366 WP_061241945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7A17_RS17805 3827344..3827676 + 333 WP_074675645.1 XRE family transcriptional regulator Antitoxin
C7A17_RS17815 3828266..3831181 + 2916 WP_106739267.1 response regulator -
C7A17_RS17820 3831199..3831444 - 246 WP_106739268.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14049.43 Da        Isoelectric Point: 4.5052

>T99804 WP_061241945.1 NZ_CP027657:3826986-3827351 [Pseudomonas mendocina]
MTWDIEYTDEFGEWWESLSAEEQESVAVSVQLLEERGPSLGFPHSSGINGSRHSHMRELRTQHEGRPYRTLYAFDPRRSA
ILLIGGDKTGDDRWYDINVPLSDRLYDEHLEQLRKEGLIDG

Download         Length: 366 bp

>T99804 NZ_CP027657:3826986-3827351 [Pseudomonas mendocina]
ATGACTTGGGATATCGAATACACCGACGAGTTCGGTGAGTGGTGGGAAAGCTTGTCTGCTGAGGAACAGGAGTCCGTTGC
GGTGTCAGTCCAGCTCCTAGAGGAGCGAGGCCCGTCACTGGGCTTTCCACACAGCAGCGGAATCAATGGCTCTCGTCACA
GCCACATGCGCGAGCTGAGGACTCAGCACGAAGGCCGACCCTACAGAACCCTGTATGCATTTGATCCCAGGCGTTCGGCT
ATTTTGCTGATCGGTGGCGACAAGACTGGTGATGATCGTTGGTATGACATCAACGTTCCGCTGTCTGATCGACTGTATGA
CGAACATCTGGAACAGCTTCGTAAGGAGGGCTTGATAGATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12264.20 Da        Isoelectric Point: 7.2052

>AT99804 WP_074675645.1 NZ_CP027657:3827344-3827676 [Pseudomonas mendocina]
MAKKFAELRAKMAPEAQARVEAKAQELLAEMPLNELRQARGLSQKVLAEVLHVQQPSIAKMEKRTDMYISTLRSHIEAMG
GQLDVIARFPDGSVKISNFSDIESDLLQQA

Download         Length: 333 bp

>AT99804 NZ_CP027657:3827344-3827676 [Pseudomonas mendocina]
ATGGCTAAGAAATTTGCAGAGCTGCGCGCAAAAATGGCGCCTGAGGCTCAGGCCAGGGTAGAGGCCAAAGCCCAGGAGCT
GCTTGCAGAGATGCCGCTTAATGAGCTGCGCCAGGCTCGTGGGCTGTCACAGAAGGTGCTGGCTGAGGTACTGCATGTAC
AGCAACCATCCATCGCCAAGATGGAAAAGCGTACTGACATGTACATTTCCACTTTGCGTAGCCACATCGAAGCCATGGGT
GGTCAGTTGGATGTCATTGCCCGGTTTCCCGATGGTTCGGTGAAGATCAGCAATTTTTCAGACATCGAAAGCGATCTTCT
CCAGCAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N3H236

Antitoxin

Source ID Structure
AlphaFold DB A0A1G6W279

References