Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1820280..1820926 Replicon chromosome
Accession NZ_CP027612
Organism Klebsiella pneumoniae subsp. ozaenae strain AR_0096

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag AM475_RS09315 Protein ID WP_004188313.1
Coordinates 1820579..1820926 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag AM475_RS09310 Protein ID WP_004188315.1
Coordinates 1820280..1820579 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM475_RS09290 1816486..1817244 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
AM475_RS09295 1817294..1818124 - 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
AM475_RS09300 1818175..1818504 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
AM475_RS09305 1818709..1820217 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
AM475_RS09310 1820280..1820579 - 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
AM475_RS09315 1820579..1820926 - 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM475_RS09320 1821102..1823549 - 2448 WP_002920561.1 glycogen phosphorylase -
AM475_RS09325 1823567..1825000 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T99774 WP_004188313.1 NZ_CP027612:c1820926-1820579 [Klebsiella pneumoniae subsp. ozaenae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T99774 NZ_CP027612:c1820926-1820579 [Klebsiella pneumoniae subsp. ozaenae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT99774 WP_004188315.1 NZ_CP027612:c1820579-1820280 [Klebsiella pneumoniae subsp. ozaenae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT99774 NZ_CP027612:c1820579-1820280 [Klebsiella pneumoniae subsp. ozaenae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References