Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2723078..2723336 Replicon chromosome
Accession NZ_CP027579
Organism Escherichia coli strain 2013C-4282

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C6996_RS13785 Protein ID WP_000809168.1
Coordinates 2723184..2723336 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2723078..2723135 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6996_RS13765 2718921..2720165 - 1245 WP_001353477.1 hypothetical protein -
C6996_RS13770 2720295..2721788 - 1494 WP_001353478.1 sulfatase-like hydrolase/transferase -
C6996_RS13775 2721809..2722570 - 762 WP_001274831.1 hypothetical protein -
- 2723078..2723135 - 58 - - Antitoxin
C6996_RS13785 2723184..2723336 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
C6996_RS13790 2723440..2724570 - 1131 WP_001118464.1 molecular chaperone DnaJ -
C6996_RS13795 2724659..2726575 - 1917 WP_000516135.1 molecular chaperone DnaK -
C6996_RS13800 2726951..2727355 + 405 WP_000843576.1 DUF2541 family protein -
C6996_RS13805 2727381..2728094 + 714 WP_106907603.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2712693..2723336 10643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T99550 WP_000809168.1 NZ_CP027579:2723184-2723336 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T99550 NZ_CP027579:2723184-2723336 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT99550 NZ_CP027579:c2723135-2723078 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References