99513

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2862896..2863691 Replicon chromosome
Accession NZ_CP027577
Organism Escherichia coli strain 2013C-4225

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C6997_RS15255 Protein ID WP_000854914.1
Coordinates 2863317..2863691 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag C6997_RS15250 Protein ID WP_001280953.1
Coordinates 2862896..2863270 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6997_RS15210 2858251..2859156 + 906 WP_000203541.1 chemotaxis protein -
C6997_RS15215 2859153..2860223 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
C6997_RS15230 2860563..2861381 + 819 WP_001234682.1 DUF945 domain-containing protein -
C6997_RS15235 2861472..2861957 + 486 WP_000214398.1 antirestriction protein -
C6997_RS15240 2861973..2862449 + 477 WP_001186738.1 RadC family protein -
C6997_RS15245 2862512..2862733 + 222 WP_000692323.1 DUF987 domain-containing protein -
C6997_RS15250 2862896..2863270 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6997_RS15255 2863317..2863691 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C6997_RS15260 2863688..2864179 + 492 WP_000976857.1 hypothetical protein -
C6997_RS15265 2864191..2864388 + 198 WP_000839282.1 DUF957 domain-containing protein -
C6997_RS15270 2864473..2865315 + 843 WP_001280481.1 DUF4942 domain-containing protein -
C6997_RS15280 2865786..2866724 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
C6997_RS15285 2866779..2867516 + 738 WP_000283664.1 zinc-binding phosphatase -
C6997_RS15290 2867540..2868094 + 555 WP_001001902.1 molecular chaperone YcdY -
C6997_RS15295 2868196..2868687 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2861973..2874252 12279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T99513 WP_000854914.1 NZ_CP027577:2863317-2863691 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T99513 NZ_CP027577:2863317-2863691 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT99513 WP_001280953.1 NZ_CP027577:2862896-2863270 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT99513 NZ_CP027577:2862896-2863270 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References