Detailed information of TA system TA099508

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1416522..1416934
• Replicon: chromosome
• Accession: NZ_CP027577
• Organism: Escherichia coli strain 2013C-4225

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: C6997_RS07570
• Protein ID: WP_000132621.1
• Coordinates: 1416522..1416863 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1416858..1416934 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6997_RS07555	1412532..1413944	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
C6997_RS07560	1414121..1414285	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
C6997_RS07565	1414382..1416475	+	2094	WP_000648228.1	DUF262 domain-containing protein	-
C6997_RS07570	1416522..1416863	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
-	1416858..1416934	+	77	NuclAT_28	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_28	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_28	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_28	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_29	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_29	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_29	-	Antitoxin
-	1416858..1416934	+	77	NuclAT_29	-	Antitoxin
C6997_RS07575	1417084..1418853	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
C6997_RS07580	1418853..1420322	-	1470	WP_001341289.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T99508 WP_000132621.1 NZ_CP027577:c1416863-1416522 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T99508 NZ_CP027577:c1416863-1416522 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT99508 NZ_CP027577:1416858-1416934 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin