Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4264016..4264604 Replicon chromosome
Accession NZ_CP027562
Organism Stenotrophomonas maltophilia strain SJTH1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag C6Y55_RS19870 Protein ID WP_080356578.1
Coordinates 4264326..4264604 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C6Y55_RS19865 Protein ID WP_049463234.1
Coordinates 4264016..4264315 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y55_RS19845 4259429..4260616 + 1188 WP_106469169.1 pyridoxal phosphate-dependent aminotransferase -
C6Y55_RS19850 4260753..4262849 - 2097 WP_106469170.1 prolyl oligopeptidase family protein -
C6Y55_RS19855 4262919..4263245 - 327 WP_106469171.1 hypothetical protein -
C6Y55_RS19860 4263373..4263975 + 603 WP_094001036.1 lipocalin family protein -
C6Y55_RS19865 4264016..4264315 - 300 WP_049463234.1 HigA family addiction module antidote protein Antitoxin
C6Y55_RS19870 4264326..4264604 - 279 WP_080356578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6Y55_RS19875 4264853..4265542 - 690 WP_014038544.1 ABC transporter permease -
C6Y55_RS19880 4265539..4266546 - 1008 WP_106469172.1 methionine ABC transporter ATP-binding protein -
C6Y55_RS19885 4266747..4267643 - 897 WP_106469173.1 DMT family transporter -
C6Y55_RS19890 4267860..4268342 + 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
C6Y55_RS19895 4268379..4269476 - 1098 WP_106469174.1 Fis family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10686.18 Da        Isoelectric Point: 9.9466

>T99471 WP_080356578.1 NZ_CP027562:c4264604-4264326 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCPRAWLSIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
NGADAVEIVDYH

Download         Length: 279 bp

>T99471 NZ_CP027562:c4264604-4264326 [Stenotrophomonas maltophilia]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGTGCCCTGTTTGAAGGAACCTGTCCACGTGCCTGGCTTTCGATCCGGCG
GGCTGCCGAGCGCAAACTCCAACTGCTCGACTCGGCACAGACGTTGGCATTCCTGCGCAGCCCGCCCGGGAACCGACTCG
AGGCGCTGTCAGGTGATCGGAGAGGGCAGTACAGCTTGCGTATCAATGACCAGTGGCGGCTGTGCTTTACCTGGACCGAC
AACGGCGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10916.62 Da        Isoelectric Point: 11.2297

>AT99471 WP_049463234.1 NZ_CP027562:c4264315-4264016 [Stenotrophomonas maltophilia]
MKRPHNGMRAIHPGEILREEFLMPLALSVNALARALDVPATRLHAIVHGERSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT99471 NZ_CP027562:c4264315-4264016 [Stenotrophomonas maltophilia]
ATGAAGCGTCCCCACAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTCCTGATGCCTCTGGCGTT
GAGCGTGAACGCGCTGGCAAGGGCCTTGGATGTTCCCGCAACACGGCTGCACGCCATCGTGCACGGGGAGCGCAGCATTT
CGGCCGATACCGCGGCACGGCTGGCGCGACATTTTGGTGGGGATGCCGCGTCCTGGCTTGCGATGCAGGCGGCCTACGAC
CTCAAGACATTGCCAACGCGCAGCGAGATCGAGCGACGGGTGCAGCCGCGGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References