Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1519572..1520074 Replicon chromosome
Accession NZ_CP027550
Organism Escherichia coli strain 2015C-4136CT1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C6950_RS08320 Protein ID WP_000767829.1
Coordinates 1519572..1519826 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C6950_RS08325 Protein ID WP_001358091.1
Coordinates 1519823..1520074 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6950_RS08300 1516065..1517423 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
C6950_RS08305 1517413..1517475 - 63 WP_097433929.1 membrane protein YoeI -
C6950_RS08310 1517690..1518619 - 930 WP_106878819.1 LysR family transcriptional regulator -
C6950_RS08315 1518665..1519489 - 825 WP_000754737.1 SDR family oxidoreductase -
C6950_RS08320 1519572..1519826 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C6950_RS08325 1519823..1520074 - 252 WP_001358091.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C6950_RS08330 1520357..1520407 + 51 WP_001364200.1 his operon leader peptide -
C6950_RS08340 1520553..1521452 + 900 WP_106878820.1 ATP phosphoribosyltransferase -
C6950_RS08345 1521458..1522762 + 1305 WP_001358092.1 histidinol dehydrogenase -
C6950_RS08350 1522759..1523829 + 1071 WP_001358093.1 histidinol-phosphate transaminase -
C6950_RS08355 1523829..1524896 + 1068 WP_001358094.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T99375 WP_000767829.1 NZ_CP027550:c1519826-1519572 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T99375 NZ_CP027550:c1519826-1519572 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.58 Da        Isoelectric Point: 4.7954

>AT99375 WP_001358091.1 NZ_CP027550:c1520074-1519823 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGESCVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT99375 NZ_CP027550:c1520074-1519823 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGTCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References