Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 1519572..1520074 | Replicon | chromosome |
Accession | NZ_CP027550 | ||
Organism | Escherichia coli strain 2015C-4136CT1 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | C6950_RS08320 | Protein ID | WP_000767829.1 |
Coordinates | 1519572..1519826 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | - |
Locus tag | C6950_RS08325 | Protein ID | WP_001358091.1 |
Coordinates | 1519823..1520074 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C6950_RS08300 | 1516065..1517423 | - | 1359 | WP_000019194.1 | putrescine/proton symporter PlaP | - |
C6950_RS08305 | 1517413..1517475 | - | 63 | WP_097433929.1 | membrane protein YoeI | - |
C6950_RS08310 | 1517690..1518619 | - | 930 | WP_106878819.1 | LysR family transcriptional regulator | - |
C6950_RS08315 | 1518665..1519489 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
C6950_RS08320 | 1519572..1519826 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
C6950_RS08325 | 1519823..1520074 | - | 252 | WP_001358091.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
C6950_RS08330 | 1520357..1520407 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
C6950_RS08340 | 1520553..1521452 | + | 900 | WP_106878820.1 | ATP phosphoribosyltransferase | - |
C6950_RS08345 | 1521458..1522762 | + | 1305 | WP_001358092.1 | histidinol dehydrogenase | - |
C6950_RS08350 | 1522759..1523829 | + | 1071 | WP_001358093.1 | histidinol-phosphate transaminase | - |
C6950_RS08355 | 1523829..1524896 | + | 1068 | WP_001358094.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T99375 WP_000767829.1 NZ_CP027550:c1519826-1519572 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T99375 NZ_CP027550:c1519826-1519572 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9323.58 Da Isoelectric Point: 4.7954
>AT99375 WP_001358091.1 NZ_CP027550:c1520074-1519823 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGESCVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGESCVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT99375 NZ_CP027550:c1520074-1519823 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGTCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGTCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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