99252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2871227..2871887 Replicon chromosome
Accession NZ_CP027539
Organism Serratia marcescens strain AR_0099

Toxin (Protein)


Gene name higB Uniprot ID A0A2V4GMA7
Locus tag AM478_RS13535 Protein ID WP_033647956.1
Coordinates 2871227..2871580 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag AM478_RS13540 Protein ID WP_033635213.1
Coordinates 2871585..2871887 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM478_RS13515 2867326..2867691 + 366 WP_033635218.1 diacylglycerol kinase -
AM478_RS13520 2867784..2868683 + 900 WP_033647959.1 LysR family transcriptional regulator -
AM478_RS13525 2868658..2869464 - 807 WP_033647958.1 substrate-binding domain-containing protein -
AM478_RS13530 2869492..2870787 - 1296 WP_033647957.1 MFS transporter -
AM478_RS13535 2871227..2871580 + 354 WP_033647956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM478_RS13540 2871585..2871887 + 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
AM478_RS13545 2872287..2873495 + 1209 WP_033647955.1 aldose 1-epimerase family protein -
AM478_RS13555 2874099..2875217 + 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
AM478_RS13560 2875343..2876257 + 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13460.30 Da        Isoelectric Point: 8.9000

>T99252 WP_033647956.1 NZ_CP027539:2871227-2871580 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T99252 NZ_CP027539:2871227-2871580 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCCACGATGCCGATCGGGCTGGCGTGCTTGC
CGCATTGATGATCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGTTCGCGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTACTTTGCGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATCCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT99252 WP_033635213.1 NZ_CP027539:2871585-2871887 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT99252 NZ_CP027539:2871585-2871887 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAAGCGCTGGCGGCTGACAT
CATGCTGAACATCCACCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCC
GGCGGCAAGCTGCGCCTGGATGTTGAACTGCCGGACGGCTCTCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4GMA7

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References