99250

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2063478..2064130 Replicon chromosome
Accession NZ_CP027539
Organism Serratia marcescens strain AR_0099

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag AM478_RS09715 Protein ID WP_033635775.1
Coordinates 2063786..2064130 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag AM478_RS09710 Protein ID WP_004931828.1
Coordinates 2063478..2063780 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM478_RS09685 2058486..2059133 - 648 WP_033649493.1 DsbA family protein -
AM478_RS09690 2059202..2060086 - 885 WP_033635778.1 MBL fold metallo-hydrolase -
AM478_RS09695 2060195..2061103 + 909 WP_015378928.1 LysR family transcriptional regulator -
AM478_RS09700 2061131..2062054 - 924 WP_033649494.1 LysR family transcriptional regulator -
AM478_RS09705 2062188..2063450 + 1263 WP_033649495.1 diaminopimelate decarboxylase -
AM478_RS09710 2063478..2063780 - 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
AM478_RS09715 2063786..2064130 - 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM478_RS09720 2064290..2065309 - 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
AM478_RS09730 2065530..2067788 + 2259 WP_033649497.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T99250 WP_033635775.1 NZ_CP027539:c2064130-2063786 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T99250 NZ_CP027539:c2064130-2063786 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT99250 WP_004931828.1 NZ_CP027539:c2063780-2063478 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT99250 NZ_CP027539:c2063780-2063478 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGATCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAACACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References