Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4732169..4732850 Replicon chromosome
Accession NZ_CP027538
Organism Pseudomonas aeruginosa strain AR_0095

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM474_RS22755 Protein ID WP_034028006.1
Coordinates 4732169..4732534 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM474_RS22760 Protein ID WP_003145733.1
Coordinates 4732527..4732850 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM474_RS22725 4728170..4728604 - 435 WP_034028004.1 RidA family protein -
AM474_RS22730 4728825..4729778 + 954 WP_003140893.1 LysR family transcriptional regulator -
AM474_RS22735 4729751..4730635 - 885 WP_009875989.1 LysR family transcriptional regulator -
AM474_RS22740 4730736..4731161 + 426 WP_003111827.1 ring-cleaving dioxygenase -
AM474_RS22745 4731192..4731464 - 273 WP_003124230.1 hypothetical protein -
AM474_RS22750 4731671..4731910 + 240 WP_044060930.1 hypothetical protein -
AM474_RS22755 4732169..4732534 + 366 WP_034028006.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM474_RS22760 4732527..4732850 + 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
AM474_RS22765 4733226..4734314 - 1089 WP_003140888.1 DUF3396 domain-containing protein -
AM474_RS22770 4734331..4735032 - 702 WP_003111822.1 VRR-NUC domain-containing protein -
AM474_RS22775 4735029..4735547 - 519 WP_003140886.1 PAAR domain-containing protein -
AM474_RS22780 4735721..4736056 - 336 WP_003140884.1 TM2 domain-containing protein -
AM474_RS22785 4736299..4736937 - 639 WP_003140882.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4712401..4736056 23655


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13838.16 Da        Isoelectric Point: 4.9885

>T99240 WP_034028006.1 NZ_CP027538:4732169-4732534 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T99240 NZ_CP027538:4732169-4732534 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGAGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCCGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCCATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT99240 WP_003145733.1 NZ_CP027538:4732527-4732850 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT99240 NZ_CP027538:4732527-4732850 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAGATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAGCTGGAAGTGATCGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCTGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References