99239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4118607..4119202 Replicon chromosome
Accession NZ_CP027538
Organism Pseudomonas aeruginosa strain AR_0095

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AM474_RS19925 Protein ID WP_071535843.1
Coordinates 4118607..4118885 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM474_RS19930 Protein ID WP_024947077.1
Coordinates 4118897..4119202 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM474_RS19905 4114032..4115270 + 1239 WP_034029043.1 C69 family dipeptidase -
AM474_RS19910 4115332..4115979 + 648 WP_003095021.1 carbonate dehydratase -
AM474_RS19915 4116050..4118278 - 2229 WP_023107900.1 TonB-dependent receptor -
AM474_RS19925 4118607..4118885 + 279 WP_071535843.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM474_RS19930 4118897..4119202 + 306 WP_024947077.1 HigA family addiction module antidote protein Antitoxin
AM474_RS19940 4119608..4120708 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
AM474_RS19945 4120749..4121333 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
AM474_RS19950 4121375..4121989 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
AM474_RS19955 4122106..4123047 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
AM474_RS19965 4123214..4124062 - 849 WP_003162406.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10674.25 Da        Isoelectric Point: 7.8937

>T99239 WP_071535843.1 NZ_CP027538:4118607-4118885 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T99239 NZ_CP027538:4118607-4118885 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGTGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11244.76 Da        Isoelectric Point: 4.6081

>AT99239 WP_024947077.1 NZ_CP027538:4118897-4119202 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLT
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT99239 NZ_CP027538:4118897-4119202 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAACA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References