Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3814791..3815443 Replicon chromosome
Accession NZ_CP027533
Organism Serratia marcescens strain AR_0091

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag AM470_RS18455 Protein ID WP_033635775.1
Coordinates 3814791..3815135 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag AM470_RS18460 Protein ID WP_004931828.1
Coordinates 3815141..3815443 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM470_RS18440 3811133..3813391 - 2259 WP_060419403.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
AM470_RS18450 3813612..3814631 + 1020 WP_060429293.1 HTH-type transcriptional regulator GalR -
AM470_RS18455 3814791..3815135 + 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM470_RS18460 3815141..3815443 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
AM470_RS18465 3815471..3816733 - 1263 WP_033649495.1 diaminopimelate decarboxylase -
AM470_RS18470 3816867..3817790 + 924 WP_033649494.1 LysR family transcriptional regulator -
AM470_RS18475 3817818..3818726 - 909 WP_015378928.1 LysR family transcriptional regulator -
AM470_RS18480 3818835..3819719 + 885 WP_039567352.1 MBL fold metallo-hydrolase -
AM470_RS18485 3819788..3820435 + 648 WP_039567349.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T99183 WP_033635775.1 NZ_CP027533:3814791-3815135 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T99183 NZ_CP027533:3814791-3815135 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT99183 WP_004931828.1 NZ_CP027533:3815141-3815443 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT99183 NZ_CP027533:3815141-3815443 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAACACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References