Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 244106..244641 | Replicon | plasmid unnamed1 |
Accession | NZ_CP027518 | ||
Organism | Enterococcus faecium strain AUSMDU00004024 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | R2PQC0 |
Locus tag | C6Y19_RS16120 | Protein ID | WP_002314366.1 |
Coordinates | 244106..244378 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q3Y220 |
Locus tag | C6Y19_RS16125 | Protein ID | WP_002297422.1 |
Coordinates | 244378..244641 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C6Y19_RS16075 | 239212..239661 | - | 450 | WP_010729386.1 | TlpA family protein disulfide reductase | - |
C6Y19_RS16700 | 239817..240359 | - | 543 | WP_002298088.1 | hypothetical protein | - |
C6Y19_RS16090 | 240634..241277 | + | 644 | Protein_269 | transposase | - |
C6Y19_RS16095 | 241353..242033 | + | 681 | WP_002331383.1 | IS6-like element IS1216 family transposase | - |
C6Y19_RS16100 | 242092..242280 | - | 189 | Protein_271 | hypothetical protein | - |
C6Y19_RS16105 | 242281..243138 | - | 858 | WP_002292680.1 | AAA family ATPase | - |
C6Y19_RS16110 | 243424..243710 | - | 287 | Protein_273 | type II toxin-antitoxin system RelE/ParE family toxin | - |
C6Y19_RS16115 | 243700..244029 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
C6Y19_RS16120 | 244106..244378 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
C6Y19_RS16125 | 244378..244641 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
C6Y19_RS16130 | 244875..245782 | + | 908 | Protein_277 | IS982 family transposase | - |
C6Y19_RS16135 | 245785..246960 | - | 1176 | WP_002336205.1 | MFS transporter | - |
C6Y19_RS16140 | 246963..249212 | - | 2250 | WP_002314387.1 | alpha-galactosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..259384 | 259384 | |
- | inside | IScluster/Tn | - | - | 232543..257132 | 24589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10780.24 Da Isoelectric Point: 9.9724
>T99154 WP_002314366.1 NZ_CP027518:c244378-244106 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T99154 NZ_CP027518:c244378-244106 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9959.22 Da Isoelectric Point: 4.5370
>AT99154 WP_002297422.1 NZ_CP027518:c244641-244378 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT99154 NZ_CP027518:c244641-244378 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F704 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F006 |