99150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 28173..28692 Replicon plasmid unnamed4
Accession NZ_CP027516
Organism Enterococcus faecium strain AUSMDU00004028

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag C6Y18_RS16510 Protein ID WP_000588503.1
Coordinates 28435..28692 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag C6Y18_RS16505 Protein ID WP_000388479.1
Coordinates 28173..28442 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y18_RS16470 23936..24352 - 417 WP_001232859.1 hypothetical protein -
C6Y18_RS16475 24355..24639 - 285 WP_000353844.1 hypothetical protein -
C6Y18_RS16480 25339..25434 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
C6Y18_RS16485 26160..26840 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
C6Y18_RS16490 26916..27482 + 567 Protein_33 hypothetical protein -
C6Y18_RS16500 27863..28042 + 180 WP_001120991.1 hypothetical protein -
C6Y18_RS16505 28173..28442 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6Y18_RS16510 28435..28692 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
C6Y18_RS16515 29329..29916 + 588 Protein_37 hypothetical protein -
C6Y18_RS16520 30071..31390 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
C6Y18_RS16525 31594..31836 + 243 Protein_39 hypothetical protein -
C6Y18_RS16530 32001..32615 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..37152 37152
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..31390 29733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T99150 WP_000588503.1 NZ_CP027516:28435-28692 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T99150 NZ_CP027516:28435-28692 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT99150 WP_000388479.1 NZ_CP027516:28173-28442 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT99150 NZ_CP027516:28173-28442 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References