Detailed information of TA system TA099150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/Txe-RelB
• Location: 28173..28692
• Replicon: plasmid unnamed4
• Accession: NZ_CP027516
• Organism: Enterococcus faecium strain AUSMDU00004028

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: Q848U6
• Locus tag: C6Y18_RS16510
• Protein ID: WP_000588503.1
• Coordinates: 28435..28692 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: Q83WJ8
• Locus tag: C6Y18_RS16505
• Protein ID: WP_000388479.1
• Coordinates: 28173..28442 (+)
• Length: 90 a.a.

Genomic Context

Location: 26916..27482 (567 bp)
Type: Others
Protein ID: Protein_33

Location: 27863..28042 (180 bp)
Type: Others
Protein ID: WP_001120991.1

Location: 28173..28442 (270 bp)
Type: Antitoxin
Protein ID: WP_000388479.1

Location: 28435..28692 (258 bp)
Type: Toxin
Protein ID: WP_000588503.1

Location: 29329..29916 (588 bp)
Type: Others
Protein ID: Protein_37

Location: 30071..31390 (1320 bp)
Type: Others
Protein ID: WP_000202380.1

Location: 31594..31836 (243 bp)
Type: Others
Protein ID: Protein_39

Location: 23936..24352 (417 bp)
Type: Others
Protein ID: WP_001232859.1

Location: 24355..24639 (285 bp)
Type: Others
Protein ID: WP_000353844.1

Location: 25339..25434 (96 bp)
Type: Others
Protein ID: WP_106913803.1

Location: 26160..26840 (681 bp)
Type: Others
Protein ID: WP_001015311.1

Location: 32001..32615 (615 bp)
Type: Others
Protein ID: WP_001261742.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6Y18_RS16470	23936..24352	-	417	WP_001232859.1	hypothetical protein	-
C6Y18_RS16475	24355..24639	-	285	WP_000353844.1	hypothetical protein	-
C6Y18_RS16480	25339..25434	-	96	WP_106913803.1	type I toxin-antitoxin system Fst family toxin	-
C6Y18_RS16485	26160..26840	-	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
C6Y18_RS16490	26916..27482	+	567	Protein_33	hypothetical protein	-
C6Y18_RS16500	27863..28042	+	180	WP_001120991.1	hypothetical protein	-
C6Y18_RS16505	28173..28442	+	270	WP_000388479.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C6Y18_RS16510	28435..28692	+	258	WP_000588503.1	Txe/YoeB family addiction module toxin	Toxin
C6Y18_RS16515	29329..29916	+	588	Protein_37	hypothetical protein	-
C6Y18_RS16520	30071..31390	+	1320	WP_000202380.1	IS1380-like element IS1678 family transposase	-
C6Y18_RS16525	31594..31836	+	243	Protein_39	hypothetical protein	-
C6Y18_RS16530	32001..32615	-	615	WP_001261742.1	recombinase family protein	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_014959 Enterococcus faecium Non-Mobilizable plasmid TA006115 1..39032 0.007	inside	Non-Mobilizable plasmid	erm(B) / ant(6)-Ia / aph(3')-III / VanHAX	-	1..37152	37152
	-	inside	IScluster/Tn	erm(B) / ant(6)-Ia / aph(3')-III / VanHAX	-	1657..31390	29733

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.53 Da
• Isoelectric Point: 8.4369

>T99150 WP_000588503.1 NZ_CP027516:28435-28692 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Nucleotide

• Length: 258 bp

>T99150 NZ_CP027516:28435-28692 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.51 Da
• Isoelectric Point: 4.4346

>AT99150 WP_000388479.1 NZ_CP027516:28173-28442 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Nucleotide

• Length: 270 bp

>AT99150 NZ_CP027516:28173-28442 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• AlphaFold DB: A0A828ZXQ8

Antitoxin

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• AlphaFold DB: A0A828ZWU7