99146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 24349..24868 Replicon plasmid unnamed4
Accession NZ_CP027510
Organism Enterococcus faecium strain AUSMDU00004055

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag C6Y17_RS15980 Protein ID WP_000588503.1
Coordinates 24611..24868 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag C6Y17_RS15975 Protein ID WP_000388479.1
Coordinates 24349..24618 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y17_RS15935 19675..20004 - 330 WP_000754864.1 metalloregulator ArsR/SmtB family transcription factor -
C6Y17_RS15940 20309..20638 + 330 WP_000629052.1 hypothetical protein -
C6Y17_RS15945 20628..20915 + 288 WP_000312842.1 type II toxin-antitoxin system RelE/ParE family toxin -
C6Y17_RS15950 21194..21757 - 564 WP_000017403.1 recombinase family protein -
C6Y17_RS16650 22156..22302 + 147 WP_159037559.1 hypothetical protein -
C6Y17_RS15955 22336..23016 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
C6Y17_RS15960 23092..23658 + 567 Protein_29 hypothetical protein -
C6Y17_RS15970 24039..24218 + 180 WP_001120991.1 hypothetical protein -
C6Y17_RS15975 24349..24618 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6Y17_RS15980 24611..24868 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
C6Y17_RS15985 25506..26093 + 588 Protein_33 hypothetical protein -
C6Y17_RS15990 26247..27566 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
C6Y17_RS15995 27770..28012 + 243 Protein_35 hypothetical protein -
C6Y17_RS16000 28177..28791 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..33328 33328
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..27566 25909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T99146 WP_000588503.1 NZ_CP027510:24611-24868 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T99146 NZ_CP027510:24611-24868 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT99146 WP_000388479.1 NZ_CP027510:24349-24618 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT99146 NZ_CP027510:24349-24618 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References