Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 217637..218172 Replicon plasmid unnamed1
Accession NZ_CP027507
Organism Enterococcus faecium strain AUSMDU00004055

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag C6Y17_RS15155 Protein ID WP_002314366.1
Coordinates 217637..217909 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag C6Y17_RS15160 Protein ID WP_002297422.1
Coordinates 217909..218172 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y17_RS15110 212744..213193 - 450 WP_010729386.1 TlpA family protein disulfide reductase -
C6Y17_RS16775 213349..213891 - 543 WP_002298088.1 hypothetical protein -
C6Y17_RS15125 214166..214809 + 644 Protein_236 transposase -
C6Y17_RS15130 214885..215565 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
C6Y17_RS15135 215624..215811 - 188 Protein_238 hypothetical protein -
C6Y17_RS15140 215812..216669 - 858 WP_002292680.1 AAA family ATPase -
C6Y17_RS15145 216955..217241 - 287 Protein_240 type II toxin-antitoxin system RelE/ParE family toxin -
C6Y17_RS15150 217231..217560 - 330 WP_002292678.1 AbrB family transcriptional regulator -
C6Y17_RS15155 217637..217909 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
C6Y17_RS15160 217909..218172 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6Y17_RS15165 218406..219314 + 909 Protein_244 IS982 family transposase -
C6Y17_RS15170 219317..220492 - 1176 WP_002336205.1 MFS transporter -
C6Y17_RS15175 220495..222744 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..231024 231024
- inside IScluster/Tn - - 206075..228773 22698


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T99144 WP_002314366.1 NZ_CP027507:c217909-217637 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T99144 NZ_CP027507:c217909-217637 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT99144 WP_002297422.1 NZ_CP027507:c218172-217909 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT99144 NZ_CP027507:c218172-217909 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References