Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 171422..171957 Replicon plasmid unnamed1
Accession NZ_CP027498
Organism Enterococcus faecium strain AUSMDU00004167

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag C6Y16_RS15635 Protein ID WP_002314366.1
Coordinates 171422..171694 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag C6Y16_RS15640 Protein ID WP_002297422.1
Coordinates 171694..171957 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6Y16_RS15600 166979..167622 + 644 Protein_167 transposase -
C6Y16_RS15605 167698..168378 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
C6Y16_RS15610 168433..168788 - 356 Protein_169 hypothetical protein -
C6Y16_RS15615 169048..169596 - 549 WP_002292681.1 hypothetical protein -
C6Y16_RS15620 169597..170454 - 858 WP_002292680.1 AAA family ATPase -
C6Y16_RS15625 170740..171026 - 287 Protein_172 type II toxin-antitoxin system RelE/ParE family toxin -
C6Y16_RS15630 171016..171345 - 330 WP_002292678.1 AbrB family transcriptional regulator -
C6Y16_RS15635 171422..171694 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
C6Y16_RS15640 171694..171957 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6Y16_RS15645 172063..172479 - 417 WP_002303153.1 hypothetical protein -
C6Y16_RS15650 172485..173048 - 564 Protein_177 IS6 family transposase -
C6Y16_RS15655 173128..174290 + 1163 WP_102642289.1 IS3 family transposase -
C6Y16_RS15660 174762..175661 - 900 WP_002303235.1 aldose 1-epimerase family protein -
C6Y16_RS15665 175682..175954 - 273 WP_002305107.1 DUF3884 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..207001 207001
- inside IScluster/Tn - - 157999..174290 16291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T99133 WP_002314366.1 NZ_CP027498:c171694-171422 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T99133 NZ_CP027498:c171694-171422 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT99133 WP_002297422.1 NZ_CP027498:c171957-171694 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT99133 NZ_CP027498:c171957-171694 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References