Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1607819..1608536 Replicon chromosome
Accession NZ_CP027482
Organism Aeromicrobium sp. A1-2

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag C6I20_RS07840 Protein ID WP_118395446.1
Coordinates 1608141..1608536 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag C6I20_RS07835 Protein ID WP_118395445.1
Coordinates 1607819..1608124 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6I20_RS07810 1603450..1604808 - 1359 WP_162891203.1 DUF262 domain-containing protein -
C6I20_RS07815 1604989..1605339 + 351 Protein_1546 single-stranded DNA-binding protein -
C6I20_RS07820 1605496..1606065 + 570 WP_118398732.1 hypothetical protein -
C6I20_RS07825 1606199..1606519 + 321 WP_118395443.1 hypothetical protein -
C6I20_RS07830 1606519..1607805 + 1287 WP_118395444.1 hypothetical protein -
C6I20_RS07835 1607819..1608124 - 306 WP_118395445.1 helix-turn-helix transcriptional regulator Antitoxin
C6I20_RS07840 1608141..1608536 - 396 WP_118395446.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6I20_RS07845 1608529..1609728 - 1200 WP_118395447.1 site-specific integrase -
C6I20_RS07850 1609744..1609965 - 222 WP_118395448.1 helix-turn-helix domain-containing protein -
C6I20_RS07855 1610253..1611429 + 1177 Protein_1554 transposase -
C6I20_RS07860 1611579..1612746 + 1168 Protein_1555 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1518128..1609783 91655


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-123)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14961.09 Da        Isoelectric Point: 8.4606

>T99129 WP_118395446.1 NZ_CP027482:c1608536-1608141 [Aeromicrobium sp. A1-2]
MNDERHTLFLVDGKGYSWVVDLELIEDWLKGADDDTYDQIIAAIRILATVGPGLGRPLVDNLVGSRRNNMKELRPGSSGR
SEVRILFAFDPKRHAIMLLAGDKQGRWDKWYRKNIPVADDRYDAHLAQVKK

Download         Length: 396 bp

>T99129 NZ_CP027482:c1608536-1608141 [Aeromicrobium sp. A1-2]
ATGAATGACGAACGTCATACCCTTTTCCTTGTAGATGGAAAAGGGTATTCTTGGGTTGTCGACCTGGAGTTGATCGAAGA
CTGGCTCAAGGGGGCAGACGACGACACCTACGACCAGATCATTGCGGCGATCCGGATCCTGGCCACCGTTGGCCCGGGAC
TGGGAAGACCGCTGGTGGACAACCTCGTGGGATCGCGACGCAACAACATGAAGGAACTACGGCCGGGTTCGTCCGGACGG
AGCGAGGTGCGGATCCTGTTCGCCTTCGACCCGAAGCGGCACGCGATCATGCTCCTGGCTGGAGACAAGCAAGGGCGCTG
GGACAAGTGGTACCGCAAGAACATCCCAGTCGCTGATGACCGGTACGACGCGCATCTGGCGCAGGTGAAGAAGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11455.12 Da        Isoelectric Point: 4.9473

>AT99129 WP_118395445.1 NZ_CP027482:c1608124-1607819 [Aeromicrobium sp. A1-2]
MGKTLEDLLVERPGNPEVQEAHMKRMLAEVRAYKLRELREMMALTQTDVAETLSVSQKRISEIERGQVDFTKVDTLRRYA
DALGGSLKVEVTVGDETYQIA

Download         Length: 306 bp

>AT99129 NZ_CP027482:c1608124-1607819 [Aeromicrobium sp. A1-2]
ATGGGCAAGACGTTGGAGGACCTGCTCGTAGAGCGGCCGGGCAACCCTGAGGTACAGGAAGCACACATGAAGCGGATGCT
CGCCGAGGTCCGTGCCTACAAGCTCCGTGAGCTGCGCGAGATGATGGCGCTTACCCAGACCGATGTCGCTGAGACGCTCT
CGGTCAGCCAGAAGCGGATCTCGGAGATCGAGCGTGGCCAGGTCGACTTCACCAAGGTCGACACCCTGCGCCGCTACGCC
GACGCTCTCGGCGGCAGCCTCAAGGTTGAGGTCACCGTGGGGGATGAGACCTACCAGATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References