99047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 140198..140456 Replicon chromosome
Accession NZ_CP027461
Organism Escherichia coli strain 95-3322

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C6W78_RS00765 Protein ID WP_000809168.1
Coordinates 140198..140350 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 140399..140456 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6W78_RS00745 135443..136156 - 714 WP_001102393.1 acidic protein MsyB -
C6W78_RS00750 136182..136586 - 405 WP_000843687.1 DUF2541 family protein -
C6W78_RS00755 136958..138874 + 1917 WP_000516135.1 molecular chaperone DnaK -
C6W78_RS00760 138963..140093 + 1131 WP_001118464.1 molecular chaperone DnaJ -
C6W78_RS00765 140198..140350 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 140399..140456 + 58 - - Antitoxin
C6W78_RS00775 140965..141726 + 762 WP_042021504.1 membrane protein -
C6W78_RS00780 141746..143239 + 1494 Protein_144 sulfatase-like hydrolase/transferase -
C6W78_RS00785 143368..144627 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T99047 WP_000809168.1 NZ_CP027461:c140350-140198 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T99047 NZ_CP027461:c140350-140198 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT99047 NZ_CP027461:140399-140456 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References