Detailed information of TA system TA098937

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2277965..2278186
• Replicon: chromosome
• Accession: NZ_CP027452
• Organism: Escherichia coli strain 2014C-3338

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: C6W71_RS11770
• Protein ID: WP_001295224.1
• Coordinates: 2278079..2278186 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2277965..2278030 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6W71_RS11745	2273406..2274308	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
C6W71_RS11750	2274319..2275302	+	984	WP_106889440.1	dipeptide ABC transporter ATP-binding protein	-
C6W71_RS11755	2275299..2276303	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
C6W71_RS11760	2276333..2277604	-	1272	WP_001318103.1	amino acid permease	-
-	2277965..2278030	-	66	-	-	Antitoxin
C6W71_RS11770	2278079..2278186	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
C6W71_RS11775	2278273..2279952	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
C6W71_RS11780	2279949..2280140	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
C6W71_RS11785	2280137..2281708	-	1572	WP_001204944.1	cellulose biosynthesis protein BcsE	-
C6W71_RS11790	2281981..2282169	+	189	WP_001063315.1	YhjR family protein	-
C6W71_RS11795	2282181..2282933	+	753	WP_000279544.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T98937 WP_001295224.1 NZ_CP027452:2278079-2278186 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T98937 NZ_CP027452:2278079-2278186 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT98937 NZ_CP027452:c2278030-2277965 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin