Detailed information of TA system TA098929

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1309198..1309610
• Replicon: chromosome
• Accession: NZ_CP027452
• Organism: Escherichia coli strain 2014C-3338

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A4T9HFU6
• Locus tag: C6W71_RS06805
• Protein ID: WP_042105859.1
• Coordinates: 1309269..1309610 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1309198..1309274 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6W71_RS06795	1305843..1307312	+	1470	WP_004996206.1	type I restriction-modification system subunit M	-
C6W71_RS06800	1307312..1309048	+	1737	WP_042105856.1	restriction endonuclease subunit S	-
-	1309198..1309274	-	77	-	-	Antitoxin
C6W71_RS06805	1309269..1309610	+	342	WP_042105859.1	endoribonuclease SymE	Toxin
C6W71_RS26025	1309657..1311750	-	2094	WP_042105862.1	DUF262 domain-containing protein	-
C6W71_RS06820	1311847..1312011	-	165	WP_000394263.1	DUF1127 domain-containing protein	-
C6W71_RS06825	1312188..1313600	+	1413	WP_000199310.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1302003..1312011	10008

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12320.21 Da
• Isoelectric Point: 9.1097

>T98929 WP_042105859.1 NZ_CP027452:1309269-1309610 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIAVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVREFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T98929 NZ_CP027452:1309269-1309610 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGCTGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAG
CTAATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCGGGAATTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT98929 NZ_CP027452:c1309274-1309198 [Escherichia coli]
AGTCATAACTGCTATTCCTTGAAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A4T9HFU6

Antitoxin