Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 136414..136840 | Replicon | plasmid unnamed |
Accession | NZ_CP027448 | ||
Organism | Escherichia coli strain 2014C-3075 |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | C6W72_RS27225 | Protein ID | WP_001312861.1 |
Coordinates | 136414..136572 (-) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 136616..136840 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C6W72_RS27175 | 131464..131691 | - | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
C6W72_RS27180 | 131785..132471 | - | 687 | WP_000332492.1 | PAS domain-containing protein | - |
C6W72_RS27185 | 132661..133044 | - | 384 | WP_000124980.1 | relaxosome protein TraM | - |
C6W72_RS27195 | 133378..133968 | + | 591 | WP_187143838.1 | transglycosylase SLT domain-containing protein | - |
C6W72_RS27200 | 134265..135086 | - | 822 | Protein_133 | DUF932 domain-containing protein | - |
C6W72_RS27205 | 135205..135492 | - | 288 | WP_106901846.1 | hypothetical protein | - |
C6W72_RS27815 | 135517..135723 | - | 207 | WP_069907064.1 | single-stranded DNA-binding protein | - |
C6W72_RS27225 | 136414..136572 | - | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
- | 136616..136840 | - | 225 | NuclAT_0 | - | Antitoxin |
- | 136616..136840 | - | 225 | NuclAT_0 | - | Antitoxin |
- | 136616..136840 | - | 225 | NuclAT_0 | - | Antitoxin |
- | 136616..136840 | - | 225 | NuclAT_0 | - | Antitoxin |
C6W72_RS27685 | 136652..136840 | + | 189 | WP_001299721.1 | hypothetical protein | - |
C6W72_RS27230 | 136852..137571 | - | 720 | WP_106901848.1 | plasmid SOS inhibition protein A | - |
C6W72_RS27235 | 137568..138002 | - | 435 | WP_032217500.1 | conjugation system SOS inhibitor PsiB | - |
C6W72_RS27240 | 138057..140015 | - | 1959 | WP_106901849.1 | ParB/RepB/Spo0J family partition protein | - |
C6W72_RS27245 | 140080..140313 | - | 234 | WP_106901850.1 | DUF905 family protein | - |
C6W72_RS27250 | 140375..140914 | - | 540 | WP_009426937.1 | single-stranded DNA-binding protein | - |
C6W72_RS27820 | 140940..141146 | - | 207 | WP_106901851.1 | single-stranded DNA-binding protein | - |
C6W72_RS27265 | 141387..141626 | - | 240 | WP_072163661.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | hlyD / hlyB / hlyA / hlyC / faeC / faeD / faeE / faeF / faeH / faeI | 1..170848 | 170848 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T98893 WP_001312861.1 NZ_CP027448:c136572-136414 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T98893 NZ_CP027448:c136572-136414 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 225 bp
>AT98893 NZ_CP027448:c136840-136616 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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