Detailed information of TA system TA098865

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-orzP/Ldr(toxin)
• Location: 515535..515756
• Replicon: chromosome
• Accession: NZ_CP027447
• Organism: Escherichia coli strain 2014C-3075

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: -
• Locus tag: C6W72_RS02745
• Protein ID: WP_096986794.1
• Coordinates: 515535..515642 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	orzP
Locus tag	-
Coordinates	515690..515756 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6W72_RS02720	511379..512461	+	1083	WP_000804726.1	peptide chain release factor 1	-
C6W72_RS02725	512461..513294	+	834	WP_000456446.1	peptide chain release factor N(5)-glutamine methyltransferase	-
C6W72_RS02730	513291..513683	+	393	WP_000200374.1	invasion regulator SirB2	-
C6W72_RS02735	513687..514496	+	810	WP_001257044.1	invasion regulator SirB1	-
C6W72_RS02740	514532..515386	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
C6W72_RS02745	515535..515642	-	108	WP_096986794.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	515690..515756	+	67	NuclAT_12	-	Antitoxin
-	515690..515756	+	67	NuclAT_12	-	Antitoxin
-	515690..515756	+	67	NuclAT_12	-	Antitoxin
-	515690..515756	+	67	NuclAT_12	-	Antitoxin
-	515690..515756	+	67	NuclAT_13	-	Antitoxin
-	515690..515756	+	67	NuclAT_13	-	Antitoxin
-	515690..515756	+	67	NuclAT_13	-	Antitoxin
-	515690..515756	+	67	NuclAT_13	-	Antitoxin
-	515690..515756	+	67	NuclAT_14	-	Antitoxin
-	515690..515756	+	67	NuclAT_14	-	Antitoxin
-	515690..515756	+	67	NuclAT_14	-	Antitoxin
-	515690..515756	+	67	NuclAT_14	-	Antitoxin
-	515690..515756	+	67	NuclAT_15	-	Antitoxin
-	515690..515756	+	67	NuclAT_15	-	Antitoxin
-	515690..515756	+	67	NuclAT_15	-	Antitoxin
-	515690..515756	+	67	NuclAT_15	-	Antitoxin
-	515690..515756	+	67	NuclAT_16	-	Antitoxin
-	515690..515756	+	67	NuclAT_16	-	Antitoxin
-	515690..515756	+	67	NuclAT_16	-	Antitoxin
-	515690..515756	+	67	NuclAT_16	-	Antitoxin
-	515690..515756	+	67	NuclAT_17	-	Antitoxin
-	515690..515756	+	67	NuclAT_17	-	Antitoxin
-	515690..515756	+	67	NuclAT_17	-	Antitoxin
-	515690..515756	+	67	NuclAT_17	-	Antitoxin
-	515692..515755	+	64	NuclAT_18	-	-
-	515692..515755	+	64	NuclAT_18	-	-
-	515692..515755	+	64	NuclAT_18	-	-
-	515692..515755	+	64	NuclAT_18	-	-
-	515692..515755	+	64	NuclAT_19	-	-
-	515692..515755	+	64	NuclAT_19	-	-
-	515692..515755	+	64	NuclAT_19	-	-
-	515692..515755	+	64	NuclAT_19	-	-
-	515692..515755	+	64	NuclAT_20	-	-
-	515692..515755	+	64	NuclAT_20	-	-
-	515692..515755	+	64	NuclAT_20	-	-
-	515692..515755	+	64	NuclAT_20	-	-
-	515692..515755	+	64	NuclAT_21	-	-
-	515692..515755	+	64	NuclAT_21	-	-
-	515692..515755	+	64	NuclAT_21	-	-
-	515692..515755	+	64	NuclAT_21	-	-
-	515692..515755	+	64	NuclAT_22	-	-
-	515692..515755	+	64	NuclAT_22	-	-
-	515692..515755	+	64	NuclAT_22	-	-
-	515692..515755	+	64	NuclAT_22	-	-
-	515692..515755	+	64	NuclAT_23	-	-
-	515692..515755	+	64	NuclAT_23	-	-
-	515692..515755	+	64	NuclAT_23	-	-
-	515692..515755	+	64	NuclAT_23	-	-
-	515692..515757	+	66	NuclAT_26	-	-
-	515692..515757	+	66	NuclAT_26	-	-
-	515692..515757	+	66	NuclAT_26	-	-
-	515692..515757	+	66	NuclAT_26	-	-
-	515692..515757	+	66	NuclAT_27	-	-
-	515692..515757	+	66	NuclAT_27	-	-
-	515692..515757	+	66	NuclAT_27	-	-
-	515692..515757	+	66	NuclAT_27	-	-
-	515692..515757	+	66	NuclAT_28	-	-
-	515692..515757	+	66	NuclAT_28	-	-
-	515692..515757	+	66	NuclAT_28	-	-
-	515692..515757	+	66	NuclAT_28	-	-
C6W72_RS02750	516047..517147	-	1101	WP_001301956.1	sodium-potassium/proton antiporter ChaA	-
C6W72_RS02755	517417..517647	+	231	WP_096986789.1	putative cation transport regulator ChaB	-
C6W72_RS02760	517805..518500	+	696	WP_096986790.1	glutathione-specific gamma-glutamylcyclotransferase	-
C6W72_RS02765	518544..518897	-	354	WP_001169670.1	DsrE/F sulfur relay family protein YchN	-
C6W72_RS02770	519082..520476	+	1395	WP_096986791.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4057.83 Da
• Isoelectric Point: 10.4338

>T98865 WP_096986794.1 NZ_CP027447:c515642-515535 [Escherichia coli]
MTLTQFAMTFWYDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T98865 NZ_CP027447:c515642-515535 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGTACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT98865 NZ_CP027447:515690-515756 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Antitoxin