Detailed information of TA system TA098770

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 32927..33180
• Replicon: plasmid unnamed1
• Accession: NZ_CP027438
• Organism: Escherichia coli strain 2012C-4221

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: C6W65_RS25670
• Protein ID: WP_106906997.1
• Coordinates: 32927..33076 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	33121..33180 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6W65_RS25625	29159..29563	-	405	WP_000154256.1	DUF2251 domain-containing protein	-
C6W65_RS25630	29733..30020	-	288	WP_000222766.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C6W65_RS25635	30017..30268	-	252	WP_001132900.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C6W65_RS25650	31231..32088	-	858	WP_158709091.1	incFII family plasmid replication initiator RepA	-
C6W65_RS25655	32081..32155	-	75	WP_001375168.1	RepA leader peptide Tap	-
C6W65_RS25665	32386..32643	-	258	WP_106906995.1	replication regulatory protein RepA	-
C6W65_RS25670	32927..33076	-	150	WP_106906997.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	33121..33180	+	60	NuclAT_0	-	Antitoxin
-	33121..33180	+	60	NuclAT_0	-	Antitoxin
-	33121..33180	+	60	NuclAT_0	-	Antitoxin
-	33121..33180	+	60	NuclAT_0	-	Antitoxin
C6W65_RS25680	33346..35490	-	2145	WP_106907000.1	peptidase domain-containing ABC transporter	-
C6W65_RS25685	35487..36770	-	1284	WP_106907002.1	HlyD family efflux transporter periplasmic adaptor subunit	-
C6W65_RS25690	37149..37724	-	576	WP_106907004.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..74904	74904

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5515.64 Da
• Isoelectric Point: 8.7678

>T98770 WP_106906997.1 NZ_CP027438:c33076-32927 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELSIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T98770 NZ_CP027438:c33076-32927 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAGTATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT98770 NZ_CP027438:33121-33180 [Escherichia coli]
AACGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin