98696

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3017363..3018056 Replicon chromosome
Accession NZ_CP027430
Organism Escherichia coli strain AS19-RrmA-

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag C6P57_RS15740 Protein ID WP_000415584.1
Coordinates 3017363..3017659 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag C6P57_RS15745 Protein ID WP_000650107.1
Coordinates 3017661..3018056 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P57_RS15700 3012451..3012765 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
C6P57_RS15705 3012796..3013377 - 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
C6P57_RS15715 3013696..3014028 + 333 WP_000917684.1 DUF2645 family protein -
C6P57_RS15720 3014074..3015423 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
C6P57_RS15725 3015420..3016079 - 660 WP_001221493.1 two-component system response regulator QseB -
C6P57_RS15730 3016231..3016623 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
C6P57_RS15735 3016676..3017158 + 483 WP_000183505.1 transcriptional regulator -
C6P57_RS15740 3017363..3017659 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
C6P57_RS15745 3017661..3018056 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
C6P57_RS15755 3018189..3019796 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
C6P57_RS15760 3019934..3022192 + 2259 WP_001281877.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T98696 WP_000415584.1 NZ_CP027430:3017363-3017659 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T98696 NZ_CP027430:3017363-3017659 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT98696 WP_000650107.1 NZ_CP027430:3017661-3018056 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT98696 NZ_CP027430:3017661-3018056 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References