Detailed information of TA system TA098671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 3327..3851
• Replicon: plasmid unnamed2
• Accession: NZ_CP027419
• Organism: Staphylococcus cohnii strain FDAARGOS_334

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CEQ12_RS00025
• Protein ID: WP_069822312.1
• Coordinates: 3585..3851 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CEQ12_RS00020
• Protein ID: WP_069822313.1
• Coordinates: 3327..3584 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ12_RS00010	123..1583	+	1461	WP_002449615.1	glucose-6-phosphate dehydrogenase	-
CEQ12_RS00015	1622..2260	+	639	WP_074381996.1	NAD(P)H-dependent oxidoreductase	-
CEQ12_RS12940	3019..3120	-	102	WP_108902203.1	type I toxin-antitoxin system Fst family toxin	-
CEQ12_RS00020	3327..3584	+	258	WP_069822313.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEQ12_RS00025	3585..3851	+	267	WP_069822312.1	Txe/YoeB family addiction module toxin	Toxin
CEQ12_RS00030	5617..6759	-	1143	WP_040029817.1	transposase	-
CEQ12_RS00035	6839..7282	+	444	WP_169926875.1	IS200/IS605 family transposase	-
CEQ12_RS00040	7453..7872	-	420	WP_040029815.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..32058	32058

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10588.99 Da
• Isoelectric Point: 9.2992

>T98671 WP_069822312.1 NZ_CP027419:3585-3851 [Staphylococcus cohnii]
MDNYSISIKNSAKSDLKKIKQSQLKTQFLKIVDTLKEDPYFPSQSFEKLQPKHLERYSRRINHQHRVVYTVDEDDKEVFI
LSAWSHYE

Nucleotide

• Length: 267 bp

>T98671 NZ_CP027419:3585-3851 [Staphylococcus cohnii]
ATGGATAATTACAGTATTTCTATTAAAAATTCAGCAAAATCTGATTTAAAGAAAATTAAACAATCGCAGTTGAAAACACA
ATTCTTAAAAATTGTAGACACGTTAAAAGAAGACCCTTATTTTCCGAGTCAATCTTTTGAAAAGTTGCAACCTAAACACT
TAGAGCGCTATTCAAGAAGAATAAACCATCAACATAGAGTTGTTTATACAGTTGATGAAGATGATAAGGAAGTTTTTATC
CTTTCTGCATGGTCACATTATGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9880.86 Da
• Isoelectric Point: 4.2797

>AT98671 WP_069822313.1 NZ_CP027419:3327-3584 [Staphylococcus cohnii]
MNIKTPTNARKEFYELLKQVNDSHEPVIISSSKSENNAVIISQKDWDSIQETLYLETTGTMDKVREREKDNSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT98671 NZ_CP027419:3327-3584 [Staphylococcus cohnii]
ATGAATATTAAAACGCCTACTAATGCTAGAAAAGAATTCTATGAACTACTTAAACAAGTTAATGATAGCCACGAACCCGT
TATTATAAGCAGTTCTAAGAGTGAAAATAACGCCGTAATTATAAGCCAAAAAGATTGGGATAGTATTCAAGAAACATTAT
ATCTTGAAACCACAGGGACTATGGATAAAGTACGAGAGCGTGAAAAGGATAACAGTGGCTACACTAATATTGATGATATA
GACTGGGACAACCTCTAA