Detailed information of TA system TA098644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2897692..2898275
• Replicon: chromosome
• Accession: NZ_CP027397
• Organism: Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0T9MER6
• Locus tag: CEQ36_RS13705
• Protein ID: WP_050073837.1
• Coordinates: 2897692..2897970 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CEQ36_RS13710
• Protein ID: WP_032906974.1
• Coordinates: 2897970..2898275 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ36_RS13695	2893407..2894354	-	948	WP_005188487.1	trehalose operon repressor TreR	-
CEQ36_RS13700	2894879..2897611	+	2733	WP_050296881.1	magnesium-translocating P-type ATPase	-
CEQ36_RS13705	2897692..2897970	+	279	WP_050073837.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ36_RS13710	2897970..2898275	+	306	WP_032906974.1	HigA family addiction module antidote protein	Antitoxin
CEQ36_RS13715	2898365..2900293	-	1929	WP_072103864.1	BglG family transcription antiterminator	-
CEQ36_RS13720	2900418..2901158	-	741	WP_050088578.1	KDGP aldolase family protein	-
CEQ36_RS13725	2901162..2902274	-	1113	WP_032906975.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10553.91 Da
• Isoelectric Point: 8.5518

>T98644 WP_050073837.1 NZ_CP027397:2897692-2897970 [Yersinia intermedia]
MIKSWKHKGLQRFFETGSAAGINPQHVKRLRGRLRFIDLAETIEDVNVAGYKLHSLQGDREGIWSVTVSGNGRITFEFKD
GDAFILNYEDYH

Nucleotide

• Length: 279 bp

>T98644 NZ_CP027397:2897692-2897970 [Yersinia intermedia]
ATGATAAAAAGTTGGAAACACAAGGGACTGCAACGCTTCTTTGAAACGGGTTCTGCCGCAGGTATTAACCCCCAGCATGT
TAAGCGACTCCGTGGCCGTTTGCGATTTATCGACTTGGCGGAAACGATTGAAGATGTCAATGTTGCTGGGTACAAACTCC
ACTCGTTACAGGGTGACAGAGAAGGGATCTGGTCAGTCACGGTAAGCGGAAACGGGCGCATCACCTTCGAGTTTAAAGAC
GGAGATGCGTTTATTCTTAACTACGAGGACTATCACTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11010.78 Da
• Isoelectric Point: 6.0643

>AT98644 WP_032906974.1 NZ_CP027397:2897970-2898275 [Yersinia intermedia]
MKMHNPPHPGEMIEGILEDLDLGIRELARALNVAPSTVQRLVSCHSAVSPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENIDISNLTKLYKPDPVSLHN

Nucleotide

• Length: 306 bp

>AT98644 NZ_CP027397:2897970-2898275 [Yersinia intermedia]
ATGAAAATGCATAATCCCCCGCATCCGGGAGAAATGATTGAAGGCATCCTCGAAGATTTGGATCTTGGGATTAGGGAGTT
AGCAAGAGCGTTAAACGTTGCGCCATCCACGGTGCAGCGGCTTGTCTCTTGTCACTCTGCGGTGTCACCGGAAATGGCGG
TGAAACTGGCGGCGGTTCTGGGAAGCACTCCGGCAATGTGGCTCCGCCTCCAGGCGGCTTACGATCTGGGGAAAGCAGAA
GAGAATATCGATATTTCAAATCTAACTAAATTGTACAAGCCGGACCCCGTATCATTGCATAACTGA

Structures

Toxin

• AlphaFold DB: A0A0T9MER6