Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1838606..1839267 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CEQ36_RS08620 Protein ID WP_050297771.1
Coordinates 1838606..1838932 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CEQ36_RS08625 Protein ID WP_042569385.1
Coordinates 1838971..1839267 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS08575 1834726..1835478 + 753 WP_032908027.1 HAD-IIA family hydrolase -
CEQ36_RS08585 1835960..1837624 + 1665 WP_050297770.1 asparagine synthase B -
CEQ36_RS08620 1838606..1838932 + 327 WP_050297771.1 hypothetical protein Toxin
CEQ36_RS08625 1838971..1839267 + 297 WP_042569385.1 helix-turn-helix domain-containing protein Antitoxin
CEQ36_RS08630 1839407..1840588 - 1182 WP_050074553.1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase -
CEQ36_RS08635 1840814..1842238 + 1425 WP_042569384.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
CEQ36_RS08640 1842535..1843608 + 1074 WP_172668594.1 PhoH family protein -
CEQ36_RS08645 1843605..1844078 + 474 WP_032905735.1 rRNA maturation RNase YbeY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12585.46 Da        Isoelectric Point: 9.4625

>T98639 WP_050297771.1 NZ_CP027397:1838606-1838932 [Yersinia intermedia]
MDFLEFVETPIFSRRRAELMSDDDFQQFQTYLLNNPQSGDTISKTGGYQKIRWGGLQRGKRGGIRVIYFVVAQRCRIWLL
LAYSKNEKDDLSESEKTVLKMITAKLDL

Download         Length: 327 bp

>T98639 NZ_CP027397:1838606-1838932 [Yersinia intermedia]
ATGGATTTCCTTGAGTTTGTAGAAACACCGATTTTTAGTCGGCGTCGAGCAGAACTAATGTCAGATGATGACTTTCAACA
ATTTCAGACTTACCTACTTAATAATCCTCAGTCTGGAGACACAATAAGCAAAACCGGGGGCTATCAAAAAATTCGATGGG
GTGGTTTGCAGCGAGGTAAACGCGGTGGTATCAGAGTTATCTATTTTGTTGTGGCCCAACGTTGTCGCATCTGGTTATTG
TTGGCTTATTCTAAAAATGAAAAAGATGATCTGTCTGAATCAGAAAAAACCGTATTGAAAATGATAACCGCTAAACTCGA
TTTATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11268.16 Da        Isoelectric Point: 7.3203

>AT98639 WP_042569385.1 NZ_CP027397:1838971-1839267 [Yersinia intermedia]
MKKELFDDLVESMNYMVAAEKGESRPKAEQIHRHPLPDVKLLRLSSGMKQEEFADIVGVSKGLVQSWEQHRRIPSGSALK
LLMMIERNPNIIEELRVL

Download         Length: 297 bp

>AT98639 NZ_CP027397:1838971-1839267 [Yersinia intermedia]
ATGAAAAAAGAACTCTTTGATGATCTGGTTGAAAGCATGAATTACATGGTCGCGGCTGAAAAAGGTGAATCACGCCCTAA
AGCAGAACAAATTCACCGTCACCCCTTACCCGATGTAAAATTATTGCGACTTTCCTCCGGCATGAAACAAGAAGAGTTCG
CAGATATCGTCGGTGTTAGCAAGGGATTGGTTCAAAGCTGGGAGCAACATCGGAGGATCCCTTCAGGTTCAGCATTAAAG
CTATTGATGATGATAGAAAGAAACCCGAATATTATTGAAGAATTACGCGTCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References