Detailed information of TA system TA098578

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1677714..1678085
• Replicon: chromosome
• Accession: NZ_CP027390
• Organism: Escherichia coli strain 2015C-4944

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: AX062_RS09905
• Protein ID: WP_001443846.1
• Coordinates: 1677936..1678085 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1677714..1677892 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AX062_RS09880	1673669..1675042	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
AX062_RS09885	1675171..1676106	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
AX062_RS09890	1676158..1677393	-	1236	WP_000040851.1	site-specific integrase	-
AX062_RS09895	1677395..1677610	-	216	WP_000079604.1	excisionase XisR	-
AX062_RS09900	1677710..1677898	-	189	WP_001302840.1	DUF1187 family protein	-
-	1677714..1677892	+	179	NuclAT_0	-	Antitoxin
-	1677714..1677892	+	179	NuclAT_0	-	Antitoxin
-	1677714..1677892	+	179	NuclAT_0	-	Antitoxin
-	1677714..1677892	+	179	NuclAT_0	-	Antitoxin
AX062_RS09905	1677936..1678085	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
AX062_RS09910	1678141..1678950	-	810	WP_000166313.1	recombination protein RecT	-
AX062_RS09915	1678943..1681543	-	2601	WP_106910098.1	exodeoxyribonuclease VIII	-
AX062_RS09920	1681645..1681920	-	276	WP_000632297.1	protein RacC	-
AX062_RS09925	1681995..1682165	-	171	WP_001352098.1	conserved protein, Rac prophage	-
AX062_RS09930	1682165..1682386	-	222	WP_000560223.1	killing protein KilR	-
AX062_RS09935	1682807..1682959	-	153	WP_001427316.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1676158..1722145	45987

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T98578 WP_001443846.1 NZ_CP027390:c1678085-1677936 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T98578 NZ_CP027390:c1678085-1677936 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT98578 NZ_CP027390:1677714-1677892 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin