Detailed information of TA system TA098530

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 972038..972409
• Replicon: chromosome
• Accession: NZ_CP027388
• Organism: Escherichia coli strain 2011C-4251

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: C6P70_RS05490
• Protein ID: WP_042853000.1
• Coordinates: 972215..972409 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	972038..972216 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P70_RS05460	967790..967963	+	174	WP_001296046.1	hypothetical protein	-
C6P70_RS05465	967993..969366	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
C6P70_RS05470	969495..970430	-	936	WP_001157382.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
C6P70_RS05475	970482..971717	-	1236	WP_000040845.1	site-specific integrase	-
C6P70_RS05480	971719..971934	-	216	WP_000079604.1	excisionase XisR	-
C6P70_RS05485	972034..972222	-	189	WP_001356607.1	DUF1187 family protein	-
-	972038..972216	+	179	NuclAT_0	-	Antitoxin
-	972038..972216	+	179	NuclAT_0	-	Antitoxin
-	972038..972216	+	179	NuclAT_0	-	Antitoxin
-	972038..972216	+	179	NuclAT_0	-	Antitoxin
C6P70_RS05490	972215..972409	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
C6P70_RS05495	972466..973275	-	810	WP_000166315.1	recombination protein RecT	-
C6P70_RS05500	973268..975937	-	2670	WP_000102194.1	exodeoxyribonuclease VIII	-
C6P70_RS05505	976018..976194	-	177	WP_000245534.1	hypothetical protein	-
C6P70_RS05510	976188..976409	-	222	WP_000560226.1	killing protein KilR	-
C6P70_RS05515	976456..977304	-	849	WP_000887681.1	Rha family phage regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	970482..1013271	42789

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T98530 WP_042853000.1 NZ_CP027388:c972409-972215 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T98530 NZ_CP027388:c972409-972215 [Escherichia coli]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT98530 NZ_CP027388:972038-972216 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin