Detailed information of TA system TA098513

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 4280187..4280558
• Replicon: chromosome
• Accession: NZ_CP027387
• Organism: Escherichia coli strain 2014C-3057

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: C6P73_RS22695
• Protein ID: WP_042853000.1
• Coordinates: 4280364..4280558 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	4280187..4280365 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P73_RS22655	4275630..4276286	-	657	WP_000011658.1	carbon-nitrogen hydrolase family protein	-
C6P73_RS22660	4276388..4276618	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
C6P73_RS22665	4276757..4277131	+	375	WP_000204699.1	CopC domain-containing protein YobA	-
C6P73_RS22670	4277135..4278007	+	873	WP_000879280.1	copper homeostasis membrane protein CopD	-
C6P73_RS22675	4278020..4278361	+	342	WP_000976492.1	YebY family protein	-
C6P73_RS22680	4278714..4279829	-	1116	WP_001189092.1	phage integrase Arm DNA-binding domain-containing protein	-
C6P73_RS22685	4279795..4280076	-	282	WP_001443927.1	excisionase	-
C6P73_RS22690	4280183..4280371	-	189	WP_001356607.1	DUF1187 family protein	-
-	4280187..4280365	+	179	NuclAT_1	-	Antitoxin
-	4280187..4280365	+	179	NuclAT_1	-	Antitoxin
-	4280187..4280365	+	179	NuclAT_1	-	Antitoxin
-	4280187..4280365	+	179	NuclAT_1	-	Antitoxin
C6P73_RS22695	4280364..4280558	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
C6P73_RS22700	4280615..4281424	-	810	WP_000166317.1	recombination protein RecT	-
C6P73_RS22705	4281417..4284068	-	2652	WP_000105101.1	exodeoxyribonuclease VIII	-
C6P73_RS22710	4284167..4284442	-	276	WP_001307773.1	hypothetical protein	-
C6P73_RS22715	4284516..4284692	-	177	WP_000245534.1	hypothetical protein	-
C6P73_RS22720	4284686..4284907	-	222	WP_000560218.1	killing protein KilR	-
C6P73_RS22725	4285328..4285480	-	153	WP_001427316.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	4272887..4343866	70979

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T98513 WP_042853000.1 NZ_CP027387:c4280558-4280364 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T98513 NZ_CP027387:c4280558-4280364 [Escherichia coli]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACAGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT98513 NZ_CP027387:4280187-4280365 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin