Detailed information of TA system TA098459

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 98068..98321
• Replicon: plasmid unnamed2
• Accession: NZ_CP027375
• Organism: Escherichia coli strain 05-3629

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: A0A148HBD8
• Locus tag: C6P66_RS26715
• Protein ID: WP_001336447.1
• Coordinates: 98068..98217 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	98265..98321 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P66_RS26675	95153..95392	-	240	WP_001365702.1	MarR family transcriptional regulator	-
C6P66_RS26680	95405..95665	-	261	WP_072127342.1	hypothetical protein	-
C6P66_RS26695	96368..97225	-	858	WP_052892418.1	incFII family plasmid replication initiator RepA	-
C6P66_RS26700	97218..97292	-	75	WP_001365705.1	RepA leader peptide Tap	-
C6P66_RS26710	97527..97784	-	258	WP_000084404.1	replication regulatory protein RepA	-
C6P66_RS26715	98068..98217	-	150	WP_001336447.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	98265..98321	+	57	NuclAT_1	-	Antitoxin
-	98265..98321	+	57	NuclAT_1	-	Antitoxin
-	98265..98321	+	57	NuclAT_1	-	Antitoxin
-	98265..98321	+	57	NuclAT_1	-	Antitoxin
C6P66_RS26730	98981..99442	-	462	WP_000760084.1	thermonuclease family protein	-
C6P66_RS26740	100538..101095	-	558	WP_024213676.1	fertility inhibition protein FinO	-
C6P66_RS26745	101131..101499	-	369	WP_052892417.1	NirD/YgiW/YdeI family stress tolerance protein	-
C6P66_RS26750	101582..102328	-	747	WP_052892416.1	type-F conjugative transfer system pilin acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	hlyD / hlyB / hlyA / hlyC / espP	1..118863	118863

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5572.69 Da
• Isoelectric Point: 8.7678

>T98459 WP_001336447.1 NZ_CP027375:c98217-98068 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T98459 NZ_CP027375:c98217-98068 [Escherichia coli]
ATGACGAAATATACCCTTATTGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT98459 NZ_CP027375:98265-98321 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A148HBD8

Antitoxin