Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 21811..22231 Replicon plasmid unnamed2
Accession NZ_CP027375
Organism Escherichia coli strain 05-3629

Toxin (Protein)


Gene name hok Uniprot ID Q2VNZ0
Locus tag C6P66_RS26205 Protein ID WP_000775238.1
Coordinates 21811..21972 (-) Length 54 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 22037..22231 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P66_RS26160 17623..18006 - 384 WP_001585112.1 relaxosome protein TraM -
C6P66_RS26165 18327..18929 + 603 WP_106916400.1 transglycosylase SLT domain-containing protein -
C6P66_RS26170 19225..20046 - 822 WP_024213651.1 DUF945 domain-containing protein -
C6P66_RS26175 20165..20452 - 288 WP_000107542.1 hypothetical protein -
C6P66_RS26185 20608..20910 - 303 WP_024213649.1 hypothetical protein -
C6P66_RS27185 21213..21510 + 298 Protein_30 hypothetical protein -
C6P66_RS26205 21811..21972 - 162 WP_000775238.1 type I toxin-antitoxin system Hok family toxin Toxin
- 22037..22231 - 195 NuclAT_0 - Antitoxin
- 22037..22231 - 195 NuclAT_0 - Antitoxin
- 22037..22231 - 195 NuclAT_0 - Antitoxin
- 22037..22231 - 195 NuclAT_0 - Antitoxin
C6P66_RS26210 22180..22494 - 315 Protein_32 theronine dehydrogenase -
C6P66_RS26215 22491..23210 - 720 WP_001276237.1 plasmid SOS inhibition protein A -
C6P66_RS26220 23207..23641 - 435 WP_024213646.1 conjugation system SOS inhibitor PsiB -
C6P66_RS26225 23696..25654 - 1959 WP_052892458.1 ParB/RepB/Spo0J family partition protein -
C6P66_RS26230 25720..25953 - 234 WP_021564200.1 DUF905 family protein -
C6P66_RS26235 26011..26544 - 534 WP_024213643.1 single-stranded DNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD / hlyB / hlyA / hlyC / espP 1..118863 118863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-48)


Sequences


Toxin        


Download         Length: 54 a.a.        Molecular weight: 5978.22 Da        Isoelectric Point: 8.5101

>T98455 WP_000775238.1 NZ_CP027375:c21972-21811 [Escherichia coli]
MKLPGNALIWCVLIVCCTLLIFTLLTRNRLCEVRLKDGYREVTATMAYESGGK

Download         Length: 162 bp

>T98455 NZ_CP027375:c21972-21811 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTGATATTCACACTCCTGACCCG
GAATCGCCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAAGTTACGGCAACAATGGCTTACGAATCCGGCGGTAAGT
AG

Antitoxin


Download         Length: 195 bp

>AT98455 NZ_CP027375:c22231-22037 [Escherichia coli]
ACTGATTGCCCGTGAACTGGCTGAACGACCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCTGGTATATGGGCT
ATGATGTGCCCGGAGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGACAAA
AGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7Z7YI12


Antitoxin

Download structure file

References