98434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2688743..2689542 Replicon chromosome
Accession NZ_CP027373
Organism Escherichia coli strain 05-3629

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag C6P66_RS13960 Protein ID WP_000347267.1
Coordinates 2688743..2689207 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag C6P66_RS13965 Protein ID WP_001307405.1
Coordinates 2689207..2689542 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P66_RS13925 2683744..2684178 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
C6P66_RS13930 2684196..2685074 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
C6P66_RS13935 2685064..2685843 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
C6P66_RS13940 2685854..2686327 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
C6P66_RS13945 2686350..2687630 - 1281 WP_097447699.1 tagatose-bisphosphate aldolase subunit KbaZ -
C6P66_RS13955 2687879..2688688 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
C6P66_RS13960 2688743..2689207 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
C6P66_RS13965 2689207..2689542 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
C6P66_RS13970 2689691..2691262 - 1572 WP_001273741.1 galactarate dehydratase -
C6P66_RS13975 2691637..2692971 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
C6P66_RS13980 2692987..2693757 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2688743..2700198 11455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T98434 WP_000347267.1 NZ_CP027373:c2689207-2688743 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T98434 NZ_CP027373:c2689207-2688743 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT98434 WP_001307405.1 NZ_CP027373:c2689542-2689207 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT98434 NZ_CP027373:c2689542-2689207 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
ACCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References