Detailed information of TA system TA098369

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 55652..55906
• Replicon: plasmid unnamed
• Accession: NZ_CP027367
• Organism: Escherichia coli strain 89-3156

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: C6P65_RS26640
• Protein ID: WP_032211975.1
• Coordinates: 55652..55858 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	55850..55906 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P65_RS26590	51311..52060	-	750	Protein_47	ISKra4-like element ISEc51 family transposase	-
C6P65_RS26595	52060..52398	+	339	Protein_48	Tn3 family transposase	-
C6P65_RS26600	52737..52976	-	240	WP_000859017.1	MarR family transcriptional regulator	-
C6P65_RS26605	52989..53249	-	261	WP_077745091.1	hypothetical protein	-
C6P65_RS26620	53951..54808	-	858	WP_028985876.1	incFII family plasmid replication initiator RepA	-
C6P65_RS26625	54801..54875	-	75	WP_001365571.1	RepA leader peptide Tap	-
C6P65_RS26635	55111..55368	-	258	WP_000084404.1	replication regulatory protein RepA	-
C6P65_RS26640	55652..55858	-	207	WP_032211975.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	55850..55906	+	57	NuclAT_1	-	Antitoxin
-	55850..55906	+	57	NuclAT_1	-	Antitoxin
-	55850..55906	+	57	NuclAT_1	-	Antitoxin
-	55850..55906	+	57	NuclAT_1	-	Antitoxin
C6P65_RS26650	56081..56464	-	384	WP_028985877.1	hypothetical protein	-
C6P65_RS26655	56567..57028	-	462	WP_000760076.1	thermonuclease family protein	-
C6P65_RS26665	58128..58685	-	558	WP_028985878.1	fertility inhibition protein FinO	-
C6P65_RS26670	58721..59089	-	369	WP_000722534.1	NirD/YgiW/YdeI family stress tolerance protein	-
C6P65_RS26675	59172..59918	-	747	WP_028985879.1	type-F conjugative transfer system pilin acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..125561	125561

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7836.33 Da
• Isoelectric Point: 9.2439

>T98369 WP_032211975.1 NZ_CP027367:c55858-55652 [Escherichia coli]
MKYLNTTDCSLFLAERSKFMTKYALIGLLAVCATVLFFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 207 bp

>T98369 NZ_CP027367:c55858-55652 [Escherichia coli]
ATGAAGTACTTGAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTTTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT98369 NZ_CP027367:55850-55906 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin